Joseph P Casazza
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Explore the profile of Joseph P Casazza including associated specialties, affiliations and a list of published articles.
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38
Citations
3718
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Recent Articles
1.
Mantus G, Chopde A, Gorman J, Cominsky L, Ourahmane A, Creanga A, et al.
Sci Transl Med
. 2025 Jan;
17(779):eadr8373.
PMID: 39742506
The conserved influenza hemagglutinin stem, which is a target of cross-neutralizing antibodies, is now used in vaccine strategies focused on protecting against influenza pandemics. Antibody responses to group 1 stem...
2.
Casazza J, Hofstetter A, Costner P, Holman L, Hendel C, Widge A, et al.
NPJ Vaccines
. 2024 Sep;
9(1):171.
PMID: 39289377
The relative conservation of the influenza hemagglutinin (HA) stem compared to that of the immunodominant HA head makes the HA stem an attractive target for broadly protective influenza vaccines. Here...
3.
Promsote W, Xu L, Hataye J, Fabozzi G, March K, Almasri C, et al.
Nat Commun
. 2023 Jun;
14(1):3719.
PMID: 37349337
Agents that can simultaneously activate latent HIV, increase immune activation and enhance the killing of latently-infected cells represent promising approaches for HIV cure. Here, we develop and evaluate a trispecific...
4.
Boswell K, Watkins T, Cale E, Samsel J, Andrews S, Ambrozak D, et al.
Front Immunol
. 2022 Dec;
13:1087018.
PMID: 36582240
The isolation and characterization of neutralizing antibodies from infection and vaccine settings informs future vaccine design, and methodologies that streamline the isolation of antibodies and the generation of B cell...
5.
Casazza J, Cale E, Narpala S, Yamshchikov G, Coates E, Hendel C, et al.
Nat Med
. 2022 Apr;
28(5):1022-1030.
PMID: 35411076
Adeno-associated viral vector-mediated transfer of DNA coding for broadly neutralizing anti-HIV antibodies (bnAbs) offers an alternative to attempting to induce protection by vaccination or by repeated infusions of bnAbs. In...
6.
Pegu A, Xu L, DeMouth M, Fabozzi G, March K, Almasri C, et al.
Cell Rep
. 2022 Jan;
38(1):110199.
PMID: 34986348
Broadly neutralizing antibodies (bNAbs) represent an alternative to drug therapy for the treatment of HIV-1 infection. Immunotherapy with single bNAbs often leads to emergence of escape variants, suggesting a potential...
7.
Hataye J, Casazza J, Best K, Liang C, Immonen T, Ambrozak D, et al.
Cell Host Microbe
. 2019 Nov;
26(6):748-763.e20.
PMID: 31761718
A population at low census might go extinct or instead transition into exponential growth to become firmly established. Whether this pivotal event occurs for a within-host pathogen can be the...
8.
Petrovas C, Ferrando-Martinez S, Gerner M, Casazza J, Pegu A, Deleage C, et al.
Sci Transl Med
. 2017 Jan;
9(373).
PMID: 28100833
Cytolytic CD8 T cells play a crucial role in the control and elimination of virus-infected cells and are a major focus of HIV cure efforts. However, it has been shown...
9.
Gach J, Gorlani A, Dotsey E, Becerra J, Anderson C, Berzins B, et al.
PLoS One
. 2016 Aug;
11(8):e0160341.
PMID: 27500639
Little is known about the humoral immune response against DNA prime-recombinant adenovirus 5 (rAd5) boost HIV vaccine among HIV-infected patients on long-term suppressive antiretroviral therapy (ART). Previous studies emphasized cellular...
10.
Boritz E, Darko S, Swaszek L, Wolf G, Wells D, Wu X, et al.
Cell
. 2016 Jul;
166(4):1004-1015.
PMID: 27453467
Targeted HIV cure strategies require definition of the mechanisms that maintain the virus. Here, we tracked HIV replication and the persistence of infected CD4 T cells in individuals with natural...