Joseph P Casazza
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Explore the profile of Joseph P Casazza including associated specialties, affiliations and a list of published articles.
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38
Citations
3718
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Recent Articles
11.
Paris R, Petrovas C, Ferrando-Martinez S, Moysi E, Boswell K, Archer E, et al.
PLoS One
. 2015 Dec;
10(12):e0144767.
PMID: 26678998
The role of PD-1 expression on CD4 T cells during HIV infection is not well understood. Here, we describe the differential expression of PD-1 in CD127high CD4 T cells within...
12.
Pegu A, Asokan M, Wu L, Wang K, Hataye J, Casazza J, et al.
Nat Commun
. 2015 Oct;
6:8447.
PMID: 26485194
The treatment of AIDS with combination antiretroviral therapy (cART) remains lifelong largely because the virus persists in latent reservoirs. Elimination of latently infected cells could therefore reduce treatment duration and...
13.
Achenbach C, Assoumou L, Deeks S, Wilkin T, Berzins B, Casazza J, et al.
Lancet HIV
. 2015 Oct;
2(3):e82-91.
PMID: 26424549
Background: Achievement of a cure for HIV infection might need reactivation of latent virus and improvement of HIV-specific immunity. As an initial step, in this trial we assessed the effect...
14.
Zhou T, Lynch R, Chen L, Acharya P, Wu X, Doria-Rose N, et al.
Cell
. 2015 May;
161(6):1280-92.
PMID: 26004070
The site on the HIV-1 gp120 glycoprotein that binds the CD4 receptor is recognized by broadly reactive antibodies, several of which neutralize over 90% of HIV-1 strains. To understand how...
15.
Ferrando-Martinez S, Ruiz-Mateos E, Casazza J, De Pablo-Bernal R, Dominguez-Molina B, Munoz-Fernandez M, et al.
J Gerontol A Biol Sci Med Sci
. 2014 Sep;
70(10):1210-8.
PMID: 25238774
Persistent cytomegalovirus (CMV) infection has been suggested to be a major driving force in the immune deterioration and an underlying source of age-related diseases in the elderly. CMV antibody titers...
16.
Zhu J, Wu X, Zhang B, McKee K, ODell S, Soto C, et al.
Proc Natl Acad Sci U S A
. 2013 Oct;
110(43):E4088-97.
PMID: 24106303
Next-generation sequencing of antibody transcripts provides a wealth of data, but the ability to identify function-specific antibodies solely on the basis of sequence has remained elusive. We previously characterized the...
17.
Chun T, Justement J, Murray D, Kim C, Blazkova J, Hallahan C, et al.
J Infect Dis
. 2013 Jul;
208(9):1443-7.
PMID: 23847057
Elite controllers suppress human immunodeficiency virus (HIV) viremia to below the limit of detection in the absence of antiretroviral therapy (ART). However, precise frequencies of CD4(+) T cells carrying replication-competent...
18.
Jarvis J, Casazza J, Stone H, Meintjes G, Lawn S, Levitz S, et al.
J Infect Dis
. 2013 Mar;
207(12):1817-28.
PMID: 23493728
Background: Correlates of immune protection in patients with human immunodeficiency virus (HIV)-associated cryptococcal meningitis are poorly defined. A clearer understanding of these immune responses is essential to inform rational development...
19.
Casazza J, Bowman K, Adzaku S, Smith E, Enama M, Bailer R, et al.
J Infect Dis
. 2013 Mar;
207(12):1829-40.
PMID: 23482645
Background: The licensing of herpes zoster vaccine has demonstrated that therapeutic vaccination can help control chronic viral infection. Unfortunately, human trials of immunodeficiency virus (HIV) vaccine have shown only marginal...
20.
Ferrando-Martinez S, Casazza J, Leal M, Machmach K, Munoz-Fernandez M, Viciana P, et al.
J Virol
. 2012 Jan;
86(7):3667-74.
PMID: 22278254
A small fraction of HIV-infected individuals (<1%), referred to as elite controllers (EC), are able to maintain undetectable viral loads indefinitely without treatment. The role of the maturational phenotype of...