Principles Governing Establishment Versus Collapse of HIV-1 Cellular Spread

Overview

Journal Cell Host Microbe

Publisher Cell Press

Specialties Infectious Diseases
Microbiology

Date 2019 Nov 26

PMID 31761718

Citations 22

Authors

Jason M Hataye

Joseph P Casazza

Katharine Best

C Jason Liang

Taina T Immonen

David R Ambrozak

Samuel Darko

Amy R Henry

Farida Laboune

Frank Maldarelli

Daniel C Douek

Nicolas W Hengartner

Takuya Yamamoto

Brandon F Keele

Alan S Perelson

Richard A Koup

Affiliations

Soon will be listed here.

Abstract

A population at low census might go extinct or instead transition into exponential growth to become firmly established. Whether this pivotal event occurs for a within-host pathogen can be the difference between health and illness. Here, we define the principles governing whether HIV-1 spread among cells fails or becomes established by coupling stochastic modeling with laboratory experiments. Following ex vivo activation of latently infected CD4 T cells without de novo infection, stochastic cell division and death contributes to high variability in the magnitude of initial virus release. Transition to exponential HIV-1 spread often fails due to release of an insufficient amount of replication-competent virus. Establishment of exponential growth occurs when virus produced from multiple infected cells exceeds a critical population size. We quantitatively define the crucial transition to exponential viral spread. Thwarting this process would prevent HIV transmission or rebound from the latent reservoir.

Citing Articles

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