Joseph Obunike
Overview
Explore the profile of Joseph Obunike including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
6
Citations
194
Followers
0
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Recent Articles
1.
Basu D, Huggins L, Scerbo D, Obunike J, Mullick A, Rothenberg P, et al.
Arterioscler Thromb Vasc Biol
. 2018 Oct;
38(9):2207-2216.
PMID: 30354257
Objective- SGLT2 (sodium-glucose cotransporter 2) inhibition in humans leads to increased levels of LDL (low-density lipoprotein) cholesterol and decreased levels of plasma triglyceride. Recent studies, however, have shown this therapy...
2.
Millar J, Lassman M, Thomas T, Ramakrishnan R, Jumes P, Dunbar R, et al.
J Lipid Res
. 2017 Mar;
58(6):1214-1220.
PMID: 28314859
Cholesteryl ester transfer protein (CETP) mediates the transfer of HDL cholesteryl esters for triglyceride (TG) in VLDL/LDL. CETP inhibition, with anacetrapib, increases HDL-cholesterol, reduces LDL-cholesterol, and lowers TG levels. This...
3.
Reyes-Soffer G, Pavlyha M, Ngai C, Thomas T, Holleran S, Ramakrishnan R, et al.
Circulation
. 2016 Dec;
135(4):352-362.
PMID: 27986651
Background: Alirocumab, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9), lowers plasma low-density lipoprotein (LDL) cholesterol and apolipoprotein B100 (apoB). Although studies in mice and cells have identified...
4.
Millar J, Reyes-Soffer G, Jumes P, Dunbar R, deGoma E, Baer A, et al.
J Clin Invest
. 2016 Apr;
126(4):1603-4.
PMID: 27035815
No abstract available.
5.
Reyes-Soffer G, Moon B, Hernandez-Ono A, Dionizovik-Dimanovski M, Dionizovick-Dimanovski M, Jimenez J, et al.
Sci Transl Med
. 2016 Jan;
8(323):323ra12.
PMID: 26819195
Mipomersen is a 20mer antisense oligonucleotide (ASO) that inhibits apolipoprotein B (apoB) synthesis; its low-density lipoprotein (LDL)-lowering effects should therefore result from reduced secretion of very-low-density lipoprotein (VLDL). We enrolled...
6.
Millar J, Reyes-Soffer G, Jumes P, Dunbar R, deGoma E, Baer A, et al.
J Clin Invest
. 2015 May;
125(6):2510-22.
PMID: 25961461
Background: Individuals treated with the cholesteryl ester transfer protein (CETP) inhibitor anacetrapib exhibit a reduction in both LDL cholesterol and apolipoprotein B (ApoB) in response to monotherapy or combination therapy...