Henry N Ginsberg
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Explore the profile of Henry N Ginsberg including associated specialties, affiliations and a list of published articles.
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205
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16404
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Recent Articles
1.
Brinton E, Eckel R, Gaudet D, Ballantyne C, Baker B, Ginsberg H, et al.
Atherosclerosis
. 2025 Mar;
403:119114.
PMID: 40068508
Familial chylomicronemia syndrome (FCS) is a rare, recessive monogenic disorder characterized by severely elevated plasma triglyceride (TG) levels due to absent or markedly impaired lipoprotein lipase activity, leading to a...
2.
Corsini A, Ginsberg H, Chapman M
Pharmacol Ther
. 2025 Feb;
268:108812.
PMID: 39947256
As a major regulator of LDL receptor (LDLR) activity and thus of LDL-cholesterol (LDL-C) levels, proprotein convertase subtilisin/kexin type 9 (PCSK9) represents an obvious therapeutic target for lipid lowering. The...
3.
Tsimikas S, Ginsberg H, Alexander V, Karwatowska-Prokopczuk E, Dibble A, Li L, et al.
J Clin Lipidol
. 2025 Jan;
PMID: 39848842
Background: Familial chylomicronemia syndrome (FCS) is diagnosed by genetic or non-genetic criteria. Objective: To assess responses to treatment of apolipoprotein (apo)C-III, triglycerides, and pancreatitis events in patients with FCS-based diagnostic...
4.
Cook J, Bedeir N, Sone Z, Wattacheril J, Ginsberg H, Laferrere B
Diabetes
. 2024 Sep;
73(12):2003-2008.
PMID: 39264822
Article Highlights:
5.
Reyes-Soffer G, Matveyenko A, Lignos J, Matienzo N, Santos Baez L, Hernandez-Ono A, et al.
Arterioscler Thromb Vasc Biol
. 2024 May;
44(6):1407-1418.
PMID: 38695168
Background: LCAT (lecithin cholesterol acyl transferase) catalyzes the conversion of unesterified, or free cholesterol, to cholesteryl ester, which moves from the surface of HDL (high-density lipoprotein) into the neutral lipid...
6.
Stroes E, Alexander V, Karwatowska-Prokopczuk E, Hegele R, Arca M, Ballantyne C, et al.
N Engl J Med
. 2024 Apr;
390(19):1781-1792.
PMID: 38587247
Background: Familial chylomicronemia syndrome is a genetic disorder associated with severe hypertriglyceridemia and severe acute pancreatitis. Olezarsen reduces the plasma triglyceride level by reducing hepatic synthesis of apolipoprotein C-III. Methods:...
7.
Liu J, Ginsberg H, Reyes-Soffer G
Curr Opin Lipidol
. 2024 Mar;
35(3):157-161.
PMID: 38465912
Purpose Of Review: Transmembrane 6 superfamily member 2 ( TM6SF2 ) gene was identified through exome-wide studies in 2014. A genetic variant from glutamic acid to lysine substitution at amino...
8.
van Zwol W, van de Sluis B, Ginsberg H, Kuivenhoven J
Circ Res
. 2024 Jan;
134(2):226-244.
PMID: 38236950
The production and secretion of VLDLs (very-low-density lipoproteins) by hepatocytes has a direct impact on liver fat content, as well as the concentrations of cholesterol and triglycerides in the circulation...
9.
Hernandez-Ono A, Zhao Y, Murray J, Ostlund C, Lee M, Shi A, et al.
JCI Insight
. 2024 Jan;
9(3).
PMID: 38194265
Depletion of torsinA from hepatocytes leads to reduced liver triglyceride secretion and marked hepatic steatosis. TorsinA is an atypical ATPase that lacks intrinsic activity unless it is bound to its...
10.
Warren R, Carew A, Andreou P, Levy A, Sapp J, Lache O, et al.
J Am Heart Assoc
. 2023 Sep;
12(19):e030288.
PMID: 37776200
Background The Hp (haptoglobin)2-2 phenotype (~40% of people) is associated with dysfunctional high-density lipoprotein (HDL) that is heavily oxidized in hyperglycemia, which may explain why raising HDL-cholesterol (HDL-C) does not...