Joseph Lehar
Overview
Explore the profile of Joseph Lehar including associated specialties, affiliations and a list of published articles.
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Articles
34
Citations
14382
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Recent Articles
31.
Lehar J, Zimmermann G, Krueger A, Molnar R, Ledell J, Heilbut A, et al.
Mol Syst Biol
. 2007 Mar;
3:80.
PMID: 17332758
Efforts to construct therapeutically useful models of biological systems require large and diverse sets of data on functional connections between their components. Here we show that cellular responses to combinations...
32.
Zimmermann G, Lehar J, Keith C
Drug Discov Today
. 2007 Jan;
12(1-2):34-42.
PMID: 17198971
Drugs designed to act against individual molecular targets cannot usually combat multigenic diseases such as cancer, or diseases that affect multiple tissues or cell types such as diabetes and immunoinflammatory...
33.
Mootha V, Lindgren C, Eriksson K, Subramanian A, Sihag S, Lehar J, et al.
Nat Genet
. 2003 Jun;
34(3):267-73.
PMID: 12808457
DNA microarrays can be used to identify gene expression changes characteristic of human disease. This is challenging, however, when relevant differences are subtle at the level of individual genes. We...
34.
Borisy A, Elliott P, Hurst N, Lee M, Lehar J, Price E, et al.
Proc Natl Acad Sci U S A
. 2003 Jun;
100(13):7977-82.
PMID: 12799470
Multicomponent therapies, originating through deliberate mixing of drugs in a clinical setting, through happenstance, and through rational design, have a successful history in a number of areas of medicine, including...