Grant R Zimmermann

Drug combinations are an increasingly favored strategy for increasing therapeutic windows for potential drugs, but enthusiasm for this approach is tempered by concerns that therapeutic synergy will too often be...

Drug combinations are a promising strategy to overcome the compensatory mechanisms and unwanted off-target effects that limit the utility of many potential drugs. However, enthusiasm for this approach is tempered...

The apparent on and off rate constants for binding of theophylline to its RNA aptamer in the absence of Mg(2+) were determined here by 2D (1)H-(1)H ZZ-exchange NMR spectroscopy. Analysis...

Introduction: Glucocorticoids are a mainstay of anti-inflammatory therapy, but significant adverse effects ultimately limit their utility. Previous efforts to design glucocorticoid structures with an increased therapeutic window have focused on...

Efforts to construct therapeutically useful models of biological systems require large and diverse sets of data on functional connections between their components. Here we show that cellular responses to combinations...

Drugs designed to act against individual molecular targets cannot usually combat multigenic diseases such as cancer, or diseases that affect multiple tissues or cell types such as diabetes and immunoinflammatory...

Multicomponent therapies, originating through deliberate mixing of drugs in a clinical setting, through happenstance, and through rational design, have a successful history in a number of areas of medicine, including...