Joseph Lehar
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Explore the profile of Joseph Lehar including associated specialties, affiliations and a list of published articles.
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34
Citations
14382
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Recent Articles
21.
Nyfeler B, Chen Y, Li X, Pinzon-Ortiz M, Wang Z, Reddy A, et al.
PLoS One
. 2012 Nov;
7(11):e48548.
PMID: 23155392
The mammalian target of rapamycin (mTOR) is regulated by oncogenic growth factor signals and plays a pivotal role in controlling cellular metabolism, growth and survival. Everolimus (RAD001) is an allosteric...
22.
Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin A, Kim S, et al.
Nature
. 2012 Mar;
483(7391):603-7.
PMID: 22460905
The systematic translation of cancer genomic data into knowledge of tumour biology and therapeutic possibilities remains challenging. Such efforts should be greatly aided by robust preclinical model systems that reflect...
23.
Suzuki Y, St Onge R, Mani R, King O, Heilbut A, Labunskyy V, et al.
Nat Methods
. 2011 Jan;
8(2):159-64.
PMID: 21217751
Phenotypes that might otherwise reveal a gene's function can be obscured by genes with overlapping function. This phenomenon is best known within gene families, in which an important shared function...
24.
Lin S, Sui J, Cotard S, Fung B, Andersen J, Zhu P, et al.
Assay Drug Dev Technol
. 2010 Nov;
8(6):669-84.
PMID: 21050065
Cystic fibrosis (CF) is an inherited, life-threatening disease caused by mutations in the gene encoding cystic fibrosis transmembrane conductance regulator (CFTR), an ABC transporter-class protein and ion channel that transports...
25.
Kim B, Kennedy D, Lehar J, Lee M, Blood A, Lee S, et al.
PLoS One
. 2010 Jun;
5(5):e10613.
PMID: 20532247
Background: Approach and avoidance behavior provide a means for assessing the rewarding or aversive value of stimuli, and can be quantified by a keypress procedure whereby subjects work to increase...
26.
Owens C, Mawhinney C, Grenier J, Altmeyer R, Lee M, Borisy A, et al.
Mol Syst Biol
. 2010 Jun;
6:375.
PMID: 20531405
The search for effective Hepatitis C antiviral therapies has recently focused on host sterol metabolism and protein prenylation pathways that indirectly affect viral replication. However, inhibition of the sterol pathway...
27.
Lehar J, Krueger A, Zimmermann G, Borisy A
Discov Med
. 2009 Dec;
8(43):185-90.
PMID: 20040268
Drug combinations are an increasingly favored strategy for increasing therapeutic windows for potential drugs, but enthusiasm for this approach is tempered by concerns that therapeutic synergy will too often be...
28.
Lehar J, Krueger A, Avery W, Heilbut A, Johansen L, Price E, et al.
Nat Biotechnol
. 2009 Jul;
27(7):659-66.
PMID: 19581876
Drug combinations are a promising strategy to overcome the compensatory mechanisms and unwanted off-target effects that limit the utility of many potential drugs. However, enthusiasm for this approach is tempered...
29.
Lehar J, Stockwell B, Giaever G, Nislow C
Nat Chem Biol
. 2008 Oct;
4(11):674-81.
PMID: 18936752
Predicting the behavior of living organisms is an enormous challenge given their vast complexity. Efforts to model biological systems require large datasets generated by physical binding experiments and perturbation studies....
30.
Lehar J, Krueger A, Zimmermann G, Borisy A
Mol Syst Biol
. 2008 Aug;
4:215.
PMID: 18682705
Biological systems are robust, in that they can maintain stable phenotypes under varying conditions or attacks. Biological systems are also complex, being organized into many functional modules that communicate through...