Joseph K Belanoff
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Explore the profile of Joseph K Belanoff including associated specialties, affiliations and a list of published articles.
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27
Citations
614
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Recent Articles
1.
Parker J, Moraitis A, Belanoff J
AACE Clin Case Rep
. 2022 Jan;
8(1):25-29.
PMID: 35097198
Background: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder in Western industrialized countries and may progress to liver injury. Cortisol is thought to play a role in...
2.
Canet G, Pineau F, Zussy C, Hernandez C, Hunt H, Chevallier N, et al.
FASEB J
. 2020 Jan;
34(1):1150-1168.
PMID: 31914623
Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis occurs early in Alzheimer's disease (AD), associated with elevated circulating glucocorticoids (GC) and glucocorticoid receptors (GR) signaling impairment. However, the precise role of GR...
3.
Koorneef L, van den Heuvel J, Kroon J, Boon M, t Hoen P, Hettne K, et al.
Endocrinology
. 2018 Oct;
159(12):3925-3936.
PMID: 30321321
Medication for nonalcoholic fatty liver disease (NAFLD) is an unmet need. Glucocorticoid (GC) stress hormones drive fat metabolism in the liver, but both full blockade and full stimulation of GC...
4.
Dalm S, Karssen A, Meijer O, Belanoff J, de Kloet E
Cell Mol Neurobiol
. 2018 Sep;
39(4):503-522.
PMID: 30173378
Psychotic depression is characterized by elevated circulating cortisol, and high daily doses of the glucocorticoid/progesterone antagonist mifepristone for 1 week are required for significant improvement. Using a rodent model, we...
5.
Hunt H, Belanoff J, Walters I, Gourdet B, Thomas J, Barton N, et al.
J Med Chem
. 2017 Apr;
60(8):3405-3421.
PMID: 28368581
The nonselective glucocorticoid receptor (GR) antagonist mifepristone has been approved in the U.S. for the treatment of selected patients with Cushing's syndrome. While this drug is highly effective, lack of...
6.
Pineau F, Canet G, Desrumaux C, Hunt H, Chevallier N, Ollivier M, et al.
Neurobiol Aging
. 2016 Jul;
45:109-122.
PMID: 27459932
In Alzheimer's disease (AD), cognitive deficits and psychological symptoms are associated with an early deregulation of the hypothalamic-pituitary-adrenal axis. Here, in an acute model of AD, we investigated if antiglucocorticoid...
7.
Teich T, Dunford E, Porras D, Pivovarov J, Beaudry J, Hunt H, et al.
Am J Physiol Endocrinol Metab
. 2016 May;
311(1):E56-68.
PMID: 27143556
Severe caloric restriction (CR), in a setting of regular physical exercise, may be a stress that sets the stage for adiposity rebound and insulin resistance when the food restriction and...
8.
Moraitis A, Block T, Nguyen D, Belanoff J
J Steroid Biochem Mol Biol
. 2016 Mar;
165(Pt A):114-120.
PMID: 27002803
Glucocorticoids (GCs) are involved in a large number of the physiological changes associated with metabolic syndrome and certain psychiatric illness. Although significance is often given to the concentration of GC,...
9.
van den Heuvel J, Boon M, van Hengel I, Peschier-van der Put E, van Beek L, van Harmelen V, et al.
Br J Pharmacol
. 2016 Mar;
173(11):1793-804.
PMID: 26990179
Background And Purpose: High-fat diet consumption results in obesity and chronic low-grade inflammation in adipose tissue. Whereas glucocorticoid receptor (GR) antagonism reduces diet-induced obesity, GR agonism reduces inflammation, the combination...
10.
Hunt H, Belanoff J, Golding E, Gourdet B, Phillips T, Swift D, et al.
Bioorg Med Chem Lett
. 2015 Nov;
25(24):5720-5.
PMID: 26546213
We report the further optimization of our series 1H-pyrazolo[3,4-g]hexahydro-isoquinoline sulfonamides as GR antagonists. By incorporating a heteroaryl ketone group at the ring junction, we have obtained compounds with excellent functional...