Joseph Goldfarb
Overview
Explore the profile of Joseph Goldfarb including associated specialties, affiliations and a list of published articles.
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22
Citations
537
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Recent Articles
1.
Hansen J, Xiong Y, Siddiq M, Dhanan P, Hu B, Shewale B, et al.
Nat Commun
. 2024 Sep;
15(1):7968.
PMID: 39261481
Drug-induced gene expression profiles can identify potential mechanisms of toxicity. We focus on obtaining signatures for cardiotoxicity of FDA-approved tyrosine kinase inhibitors (TKIs) in human induced-pluripotent-stem-cell-derived cardiomyocytes, using bulk transcriptomic...
2.
White P, Guilding C, Angelo T, Kelly J, Gorman L, Tucker S, et al.
Br J Pharmacol
. 2022 Dec;
180(9):1197-1209.
PMID: 36470846
Background And Purpose: In recent decades, a focus on the most critical and fundamental concepts has proven highly advantageous to students and educators in many science disciplines. Pharmacology, unlike microbiology,...
3.
Hansen J, Siddiq M, Yadaw A, Tolentino R, Rabinovich V, Jayaraman G, et al.
J Biol Chem
. 2022 Aug;
298(10):102325.
PMID: 35926710
Neurite outgrowth is an integrated whole cell response triggered by the cannabinoid-1 receptor. We sought to identify the many different biochemical pathways that contribute to this whole cell response. To...
4.
Xiong Y, Liu T, Chen T, Hansen J, Hu B, Chen Y, et al.
Sci Data
. 2022 Jan;
9(1):18.
PMID: 35058449
Drug Toxicity Signature Generation Center (DToxS) at the Icahn School of Medicine at Mount Sinai is one of the centers for the NIH Library of Integrated Network-Based Cellular Signatures (LINCS)...
5.
Schaniel C, Dhanan P, Hu B, Xiong Y, Raghunandan T, Gonzalez D, et al.
Stem Cell Reports
. 2021 Nov;
16(12):3036-3049.
PMID: 34739849
A library of well-characterized human induced pluripotent stem cell (hiPSC) lines from clinically healthy human subjects could serve as a useful resource of normal controls for in vitro human development,...
6.
Siddiq M, Chan A, Miorin L, Yadaw A, Beaumont K, Kehrer T, et al.
J Virol
. 2021 Oct;
96(2):e0106321.
PMID: 34669512
COVID-19 affects multiple organs. Clinical data from the Mount Sinai Health System show that substantial numbers of COVID-19 patients without prior heart disease develop cardiac dysfunction. How COVID-19 patients develop...
7.
Siddiq M, Chan A, Miorin L, Yadaw A, Beaumont K, Kehrer T, et al.
medRxiv
. 2020 Nov;
PMID: 33200140
COVID-19 affects multiple organs. Clinical data from the Mount Sinai Health System shows that substantial numbers of COVID-19 patients without prior heart disease develop cardiac dysfunction. How COVID-19 patients develop...
8.
van Hasselt J, Rahman R, Hansen J, Stern A, Shim J, Xiong Y, et al.
Nat Commun
. 2020 Sep;
11(1):4809.
PMID: 32968055
Kinase inhibitors (KIs) represent an important class of anti-cancer drugs. Although cardiotoxicity is a serious adverse event associated with several KIs, the reasons remain poorly understood, and its prediction remains...
9.
Tavassoly I, Hu Y, Zhao S, Mariottini C, Boran A, Chen Y, et al.
Mol Oncol
. 2019 May;
13(8):1725-1743.
PMID: 31116490
The ability to predict responsiveness to drugs in individual patients is limited. We hypothesized that integrating molecular information from databases would yield predictions that could be experimentally tested to develop...
10.
Tavassoly I, Goldfarb J, Iyengar R
Essays Biochem
. 2018 Oct;
62(4):487-500.
PMID: 30287586
Systems biology is an integrative discipline connecting the molecular components within a single biological scale and also among different scales (e.g. cells, tissues and organ systems) to physiological functions and...