Joseph C Gonzalez
Overview
Explore the profile of Joseph C Gonzalez including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
248
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Recent Articles
1.
Chakraborty S, Cheng B, Edwards D, Gonzalez J, Chiu D, Zheng H, et al.
Immunity
. 2024 Nov;
58(1):182-196.e10.
PMID: 39541970
While most respiratory viral infections resolve with little harm to the host, severe symptoms arise when infection triggers an aberrant inflammatory response that damages lung tissue. Host regulators of virally...
2.
Archer E, Gonzalez J, Ghosh D, Mellins E, Wang T
Curr Opin Immunol
. 2022 Jul;
77:102231.
PMID: 35797920
The effector activity of IgG antibodies is regulated at several levels, including IgG subclass, modifications of the Fc glycan, and the distribution of Type I and II Fcγ receptors (FcγR)...
3.
Gonzalez J, Chakraborty S, Thulin N, Wang T
Immunol Rev
. 2022 Jul;
309(1):64-74.
PMID: 35781671
In this review, we discuss how IgG antibodies can modulate inflammatory signaling during viral infections with a focus on CD16a-mediated functions. We describe the structural heterogeneity of IgG antibody ligands,...
4.
Ackerman S, Pearson C, Gregorio J, Gonzalez J, Kenkel J, Hartmann F, et al.
Nat Cancer
. 2022 Feb;
2(1):18-33.
PMID: 35121890
Innate pattern recognition receptor agonists, including Toll-like receptors (TLRs), alter the tumor microenvironment and prime adaptive antitumor immunity. However, TLR agonists present toxicities associated with widespread immune activation after systemic...
5.
Chakraborty S, Gonzalez J, Sievers B, Mallajosyula V, Chakraborty S, Dubey M, et al.
Sci Transl Med
. 2022 Jan;
14(635):eabm7853.
PMID: 35040666
A damaging inflammatory response is implicated in the pathogenesis of severe coronavirus disease 2019 (COVID-19), but mechanisms contributing to this response are unclear. In two prospective cohorts, early non-neutralizing, afucosylated...
6.
Sievers B, Chakraborty S, Xue Y, Gelbart T, Gonzalez J, Cassidy A, et al.
Sci Transl Med
. 2022 Jan;
14(634):eabn7842.
PMID: 35025672
Multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants that have mutations associated with increased transmission and antibody escape have arisen over the course of the current pandemic. Although the...
7.
Gonzalez J, Wang T
Immunity
. 2021 Aug;
54(9):1912-1914.
PMID: 34464594
Monoclonal antibodies show efficacy in treating COVID-19, but the functional requirements for protection are unclear. In this issue of Immunity, Ullah et al. (2021) develop a stable SARS-CoV-2 reporter virus...
8.
Chakraborty S, Gonzalez J, Sievers B, Mallajosyula V, Chakraborty S, Dubey M, et al.
bioRxiv
. 2021 Jun;
PMID: 34075376
One Sentence Summary: Divergent early antibody responses predict COVID-19 disease trajectory and mRNA vaccine response and are functionally distinct .
9.
Alonso M, Gregorio J, Davidson M, Gonzalez J, Engleman E
Immunol Res
. 2014 May;
58(2-3):374-7.
PMID: 24781193
Monocytes rapidly infiltrate inflamed tissues and differentiate into CD209(+) inflammatory dendritic cells (DCs) that promote robust immunity or, if unregulated, inflammatory disease. Previous studies in experimental animal models indicate that...
10.
Davidson M, Alonso M, Kenkel J, Suhoski M, Gonzalez J, Yuan R, et al.
PLoS One
. 2013 Oct;
8(10):e76258.
PMID: 24098455
Two critical functions of dendritic cells (DC) are to activate and functionally polarize T cells. Activated T cells can, in turn, influence DC maturation, although their effect on de novo...