Heterogeneity in IgG-CD16 Signaling in Infectious Disease Outcomes

Overview

Journal Immunol Rev

Specialties Allergy & Immunology
General Surgery

Date 2022 Jul 5

PMID 35781671

Authors

Joseph C Gonzalez

Saborni Chakraborty

Natalie K Thulin

Taia T Wang

Affiliations

Soon will be listed here.

Abstract

In this review, we discuss how IgG antibodies can modulate inflammatory signaling during viral infections with a focus on CD16a-mediated functions. We describe the structural heterogeneity of IgG antibody ligands, including subclass and glycosylation that impact binding by and downstream activity of CD16a, as well as the heterogeneity of CD16a itself, including allele and expression density. While inflammation is a mechanism required for immune homeostasis and resolution of acute infections, we focus here on two infectious diseases that are driven by pathogenic inflammatory responses during infection. Specifically, we review and discuss the evolving body of literature showing that afucosylated IgG immune complex signaling through CD16a contributes to the overwhelming inflammatory response that is central to the pathogenesis of severe forms of dengue disease and coronavirus disease 2019 (COVID-19).

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