Edgar G Engleman
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Explore the profile of Edgar G Engleman including associated specialties, affiliations and a list of published articles.
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95
Citations
5891
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Recent Articles
1.
Melemenidis S, Nguyen K, Baraceros-Pineda R, Barclay C, Bautista J, Lau H, et al.
bioRxiv
. 2024 Dec;
PMID: 39713317
Background And Objectives: Apheresis platelets products and plasma are essential for medical interventions, but both still have inherent risks associated with contamination and viral transmission. Platelet products are vulnerable to...
2.
Wen R, Stark J, Marti G, Fan Z, Lyu A, Marques F, et al.
J Clin Invest
. 2024 Oct;
134(24).
PMID: 39436703
Prostate cancer is the second leading cause of male cancer death in the U.S. Current immune checkpoint inhibitor-based immunotherapies have improved survival for many malignancies; however, they have failed to...
3.
Bagchi S, Yuan R, Huang H, Zhang W, Chiu D, Kim H, et al.
Sci Immunol
. 2024 Oct;
9(100):eadg6453.
PMID: 39423285
Multiple cancers, including colorectal cancer (CRC), are more frequent and often more aggressive in individuals with obesity. Here, we showed that macrophages accumulated within tumors of patients with obesity and...
4.
Sun J, Zhang Y, Zhang Q, Hu L, Zhao L, Wang H, et al.
Immunity
. 2024 May;
57(6):1289-1305.e9.
PMID: 38772366
Adipose tissue group 2 innate lymphoid cells (ILC2s) help maintain metabolic homeostasis by sustaining type 2 immunity and promoting adipose beiging. Although impairment of the ILC2 compartment contributes to obesity-associated...
5.
Fan W, Adebowale K, Vancza L, Li Y, Rabbi M, Kunimoto K, et al.
Nature
. 2024 Jan;
626(7999):635-642.
PMID: 38297127
Type 2 diabetes mellitus is a major risk factor for hepatocellular carcinoma (HCC). Changes in extracellular matrix (ECM) mechanics contribute to cancer development, and increased stiffness is known to promote...
6.
Reticker-Flynn N, Engleman E
Trends Cell Biol
. 2023 May;
33(12):1021-1034.
PMID: 37149414
Metastasis to lymph nodes (LNs) is a common feature of disease progression in most solid organ malignancies. Consequently, LN biopsy and lymphadenectomy are common clinical practices, not only because of...
7.
Linde I, Prestwood T, Qiu J, Pilarowski G, Linde M, Zhang X, et al.
Cancer Cell
. 2023 Jan;
41(2):356-372.e10.
PMID: 36706760
Despite their cytotoxic capacity, neutrophils are often co-opted by cancers to promote immunosuppression, tumor growth, and metastasis. Consequently, these cells have received little attention as potential cancer immunotherapeutic agents. Here,...
8.
Zhang W, Li I, Reticker-Flynn N, Good Z, Chang S, Samusik N, et al.
Nat Methods
. 2022 Jun;
19(6):759-769.
PMID: 35654951
Advances in multiplexed in situ imaging are revealing important insights in spatial biology. However, cell type identification remains a major challenge in imaging analysis, with most existing methods involving substantial...
9.
Reticker-Flynn N, Zhang W, Belk J, Basto P, Escalante N, Pilarowski G, et al.
Cell
. 2022 May;
185(11):1924-1942.e23.
PMID: 35525247
For many solid malignancies, lymph node (LN) involvement represents a harbinger of distant metastatic disease and, therefore, an important prognostic factor. Beyond its utility as a biomarker, whether and how...
10.
Ackerman S, Pearson C, Gregorio J, Gonzalez J, Kenkel J, Hartmann F, et al.
Nat Cancer
. 2022 Feb;
2(1):18-33.
PMID: 35121890
Innate pattern recognition receptor agonists, including Toll-like receptors (TLRs), alter the tumor microenvironment and prime adaptive antitumor immunity. However, TLR agonists present toxicities associated with widespread immune activation after systemic...