Joseph A Jude
Overview
Explore the profile of Joseph A Jude including associated specialties, affiliations and a list of published articles.
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21
Citations
337
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Recent Articles
1.
Jude J, Panettieri Jr R
Trends Pharmacol Sci
. 2025 Jan;
46(3):201-203.
PMID: 39824674
Inflammatory lung diseases represent a significant healthcare burden. There is an unmet need for identifying therapeutic targets for inflammatory lung diseases, such as asthma, and chronic obstructive pulmonary disease (COPD)....
2.
Woo J, Cao G, Karmacharya N, Lee J, Lee J, Duru K, et al.
Am J Respir Cell Mol Biol
. 2024 Oct;
PMID: 39470451
Leucine-rich repeat containing 8A (LRRC8A) is an obligatory constituent of the volume-regulated anion channel (VRAC) that is fundamental to a wide range of biological processes, including regulating cell size, proliferation,...
3.
Jude J, Panettieri Jr R
Expert Rev Respir Med
. 2024 Oct;
18(11):835-841.
PMID: 39435484
Introduction: Obstructive airway diseases asthma and COPD represent a significant healthcare burden. Airway hyperresponsiveness (AHR), a salient feature of these two diseases, remains the main therapeutic target. Airway smooth muscle...
4.
Xu S, Karmacharya N, Woo J, Cao G, Guo C, Gow A, et al.
Am J Respir Cell Mol Biol
. 2022 Oct;
68(1):39-48.
PMID: 36227725
Bronchomotor tone modulated by airway smooth muscle shortening represents a key mechanism that increases airway resistance in asthma. Altered glucose metabolism in inflammatory and airway structural cells is associated with...
5.
Yon C, Thompson D, Jude J, Panettieri Jr R, Rastogi D
Am J Respir Crit Care Med
. 2022 Oct;
207(4):461-474.
PMID: 36194662
Pediatric obesity-related asthma is a nonatopic asthma phenotype with high disease burden and few effective therapies. RhoGTPase upregulation in peripheral blood T helper (Th) cells is associated with the phenotype,...
6.
Xu S, Karmacharya N, Cao G, Guo C, Gow A, Panettieri Jr R, et al.
Am J Physiol Lung Cell Mol Physiol
. 2022 Jul;
323(3):L297-L307.
PMID: 35787188
Obesity can aggravate asthma by enhancing airway hyperresponsiveness (AHR) and attenuating response to treatment. However, the precise mechanisms linking obesity and asthma remain unknown. Human airway smooth muscle (HASM) cells...
7.
Cao G, Lam H, Jude J, Karmacharya N, Kan M, Jester W, et al.
Am J Respir Cell Mol Biol
. 2021 Oct;
66(1):96-106.
PMID: 34648729
In most living cells, the second-messenger roles for adenosine 3',5'-cyclic monophosphate (cAMP) are short-lived, confined to the intracellular space, and tightly controlled by the binary switch-like actions of Gα (stimulatory...
8.
Xu S, Schwab A, Karmacharya N, Cao G, Woo J, Kim N, et al.
Respir Res
. 2020 Dec;
21(1):317.
PMID: 33256729
Background: Activation of free fatty acid receptors (FFAR1 and FFAR4) which are G protein-coupled receptors (GPCRs) with established (patho)physiological roles in a variety of obesity-related disorders, induce human airway smooth...
9.
Guedes A, Dileepan M, Jude J, Deshpande D, Walseth T, Kannan M
Curr Opin Pharmacol
. 2020 Jun;
51:29-33.
PMID: 32480246
The worldwide socioeconomical burden associated with chronic respiratory diseases is substantial. Enzymes involved in the metabolism of nicotinamide adenine dinucleotide (NAD) are increasingly being implicated in chronic airway diseases. One...
10.
Wong G, Redes J, Balenga N, McCullough M, Fuentes N, Gokhale A, et al.
J Allergy Clin Immunol
. 2020 Mar;
146(5):1152-1164.e13.
PMID: 32199913
Background: Allergens elicit host production of mediators acting on G-protein-coupled receptors to regulate airway tone. Among these is prostaglandin E2 (PGE2), which, in addition to its role as a bronchodilator,...