Mathur S Kannan
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Explore the profile of Mathur S Kannan including associated specialties, affiliations and a list of published articles.
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39
Citations
855
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Recent Articles
1.
Dogan S, Walseth T, Guvenc Tuna B, Ucar E, Kannan M, Deshpande D
IUBMB Life
. 2024 Aug;
76(12):1223-1233.
PMID: 39135342
Cyclic ADP-ribose (cADPR) has emerged as a calcium-regulating second messenger in smooth muscle cells. CD38 protein possesses ADP-ribosyl cyclase and cADPR hydrolase activities and mediates cADPR synthesis and degradation. We...
2.
Krishnan R, Kannan M, Deshpande D
AJP Rep
. 2024 May;
14(2):e162-e169.
PMID: 38784940
Superoxide anions (O ) have multiple effects on pulmonary parenchyma altering cell proliferation, cellular metabolism, and airway smooth muscle (ASM) contraction. Intracellular calcium ([Ca ] ) concentration plays a significant...
3.
Guedes A, Dileepan M, Jude J, Deshpande D, Walseth T, Kannan M
Curr Opin Pharmacol
. 2020 Jun;
51:29-33.
PMID: 32480246
The worldwide socioeconomical burden associated with chronic respiratory diseases is substantial. Enzymes involved in the metabolism of nicotinamide adenine dinucleotide (NAD) are increasingly being implicated in chronic airway diseases. One...
4.
Deshpande D, Guedes A, Graeff R, Dogan S, Subramanian S, Walseth T, et al.
Mediators Inflamm
. 2018 Mar;
2018:8942042.
PMID: 29576747
Asthma is an inflammatory disease in which proinflammatory cytokines have a role in inducing abnormalities of airway smooth muscle function and in the development of airway hyperresponsiveness. Inflammatory cytokines alter...
5.
Deshpande D, Guedes A, Lund F, Subramanian S, Walseth T, Kannan M
Pharmacol Ther
. 2016 Dec;
172:116-126.
PMID: 27939939
CD38 is an ectoenzyme that catalyzes the conversion of β-nicotinamide adenine dinucleotide (β-NAD) to cyclic adenosine diphosphoribose (cADPR) and adenosine diphosphoribose (ADPR) and NADP to nicotinic acid adenine dinucleotide phosphate...
6.
Dileepan M, Sarver A, Rao S, Panettieri Jr R, Subramanian S, Kannan M
PLoS One
. 2016 Mar;
11(3):e0150842.
PMID: 26998837
Airway smooth muscle (ASM) cells play a critical role in the pathophysiology of asthma due to their hypercontractility and their ability to proliferate and secrete inflammatory mediators. microRNAs (miRNAs) are...
7.
Guedes A, Deshpande D, Dileepan M, Walseth T, Panettieri Jr R, Subramanian S, et al.
Can J Physiol Pharmacol
. 2015 Jan;
93(2):145-53.
PMID: 25594684
Asthma is an inflammatory disease in which altered calcium regulation, contractility, and airway smooth muscle (ASM) proliferation contribute to airway hyper-responsiveness and airway wall remodeling. The enzymatic activity of CD38,...
8.
Guedes A, Jude J, Paulin J, Rivero-Nava L, Kita H, Lund F, et al.
Am J Physiol Lung Cell Mol Physiol
. 2015 Jan;
308(5):L485-93.
PMID: 25575514
CD38 is a cell-surface protein involved in calcium signaling and contractility of airway smooth muscle. It has a role in normal airway responsiveness and in airway hyperresponsiveness (AHR) developed following...
9.
Dileepan M, Jude J, Rao S, Walseth T, Panettieri R, Subramanian S, et al.
Respir Res
. 2014 Sep;
15:107.
PMID: 25175907
Background: The cell-surface protein CD38 mediates airway smooth muscle (ASM) contractility by generating cyclic ADP-ribose, a calcium-mobilizing molecule. In human ASM cells, TNF-α augments CD38 expression transcriptionally by NF-κB and...
10.
Guedes A, Rude E, Kannan M
Vet Anaesth Analg
. 2013 Apr;
40(5):512-6.
PMID: 23565906
Objective: To investigate the CD38/cADPR signaling pathway as possible underlying mechanism of the effects of medetomidine on insulin and glucose homeostasis. Animals: Thirty-two C57BL/6 mice of both sexes. Methods: Wild-type...