Josee Hamelin
Overview
Explore the profile of Josee Hamelin including associated specialties, affiliations and a list of published articles.
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Articles
28
Citations
1292
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Recent Articles
1.
Sachan V, LeDevehat M, Roubtsova A, Essalmani R, Laurendeau J, Garcon D, et al.
Metabolism
. 2024 Sep;
161:156032.
PMID: 39298889
No abstract available.
2.
Sachan V, Le Devehat M, Roubtsova A, Essalmani R, Laurendeau J, Garcon D, et al.
Metabolism
. 2023 Nov;
150:155736.
PMID: 37967646
Background: Epidemiological evidence links the proprotein convertase subtilisin/kexin 7 (PCSK7) to triglyceride (TG) metabolism. We associated the known PCSK7 gain-of-function non-coding SNP rs236918 with higher levels of plasma apolipoprotein B...
3.
Ashraf Y, Duval S, Sachan V, Essalmani R, Susan-Resiga D, Roubtsova A, et al.
FEBS J
. 2020 Jan;
287(16):3565-3578.
PMID: 31945259
The locus of the human proprotein convertase subtilisin-kexin type-7 (PC7) gene (PCSK7) is on chromosome 11q23.3 close to the gene cluster APOA5/APOA4/APOC3/APOA1, a region implicated in the regulation of lipoprotein...
4.
Ben Djoudi Ouadda A, Gauthier M, Susan-Resiga D, Girard E, Essalmani R, Black M, et al.
Arterioscler Thromb Vasc Biol
. 2019 Sep;
39(10):1996-2013.
PMID: 31553664
Objective: PCSK9 (proprotein convertase subtilisin-kexin 9) enhances the degradation of the LDLR (low-density lipoprotein receptor) in endosomes/lysosomes. This study aimed to determine the sites of PCSK9 phosphorylation at Ser-residues and...
5.
Sachan V, Lodge R, Mihara K, Hamelin J, Power C, Gelman B, et al.
Cell Death Differ
. 2019 Jan;
26(10):1942-1954.
PMID: 30683917
HIV-associated neurocognitive disorders (HAND) is a syndrome defined by neurocognitive deficits that are driven by viral neurotoxins, cytokines, free radicals, and proteases expressed in the brain. This neurological disease has...
6.
Elbitar S, Susan-Resiga D, Ghaleb Y, Khoury P, Peloso G, Stitziel N, et al.
Sci Rep
. 2018 Feb;
8(1):1943.
PMID: 29386597
Autosomal dominant hypercholesterolemia (ADH) is characterized by elevated LDL-C levels leading to coronary heart disease. Four genes are implicated in ADH: LDLR, APOB, PCSK9 and APOE. Our aim was to...
7.
Susan-Resiga D, Girard E, Kiss R, Essalmani R, Hamelin J, Asselin M, et al.
J Biol Chem
. 2016 Dec;
292(5):1573-1590.
PMID: 27998977
Familial hypercholesterolemia (FH) is characterized by severely elevated low density lipoprotein (LDL) cholesterol. Herein, we identified an FH patient presenting novel compound heterozygote mutations R410S and G592E of the LDL...
8.
Weider E, Susan-Resiga D, Essalmani R, Hamelin J, Asselin M, Nimesh S, et al.
J Biol Chem
. 2016 Dec;
291(51):26586.
PMID: 27986868
No abstract available.
9.
Weider E, Susan-Resiga D, Essalmani R, Hamelin J, Asselin M, Nimesh S, et al.
J Biol Chem
. 2016 Jun;
291(32):16659-71.
PMID: 27284008
Single domain antibodies (sdAbs) correspond to the antigen-binding domains of camelid antibodies. They have the same antigen-binding properties and specificity as monoclonal antibodies (mAbs) but are easier and cheaper to...
10.
Butkinaree C, Canuel M, Essalmani R, Poirier S, Benjannet S, Asselin M, et al.
J Biol Chem
. 2015 Jun;
290(30):18609-20.
PMID: 26085104
Amyloid precursor-like protein 2 (APLP2) and sortilin were reported to individually bind the proprotein convertase subtilisin/kexin type 9 (PCSK9) and regulate its activity on the low-density lipoprotein receptor (LDLR). The...