Jadwiga Marcinkiewicz
Overview
Explore the profile of Jadwiga Marcinkiewicz including associated specialties, affiliations and a list of published articles.
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17
Citations
1364
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Recent Articles
1.
Roubtsova A, Garcon D, Lacoste S, Chamberland A, Marcinkiewicz J, Metivier R, et al.
Biochim Biophys Acta Mol Cell Biol Lipids
. 2022 Aug;
1867(12):159217.
PMID: 35985474
PCSK9 promotes the lysosomal degradation of cell surface LDL receptor (LDLR). We analyzed how excess LDLR generated by PCSK9 deficiency is differently handled in male and female mice to possibly...
2.
Susan-Resiga D, Girard E, Essalmani R, Roubtsova A, Marcinkiewicz J, Derbali R, et al.
J Biol Chem
. 2021 Sep;
297(4):101177.
PMID: 34508778
The hepatic carbohydrate-recognizing asialoglycoprotein receptor (ASGR1) mediates the endocytosis/lysosomal degradation of desialylated glycoproteins following binding to terminal galactose/N-acetylgalactosamine. Human heterozygote carriers of ASGR1 deletions exhibit ∼34% lower risk of coronary...
3.
Ben Djoudi Ouadda A, Gauthier M, Susan-Resiga D, Girard E, Essalmani R, Black M, et al.
Arterioscler Thromb Vasc Biol
. 2019 Sep;
39(10):1996-2013.
PMID: 31553664
Objective: PCSK9 (proprotein convertase subtilisin-kexin 9) enhances the degradation of the LDLR (low-density lipoprotein receptor) in endosomes/lysosomes. This study aimed to determine the sites of PCSK9 phosphorylation at Ser-residues and...
4.
Essalmani R, Weider E, Marcinkiewicz J, Chamberland A, Susan-Resiga D, Roubtsova A, et al.
Biol Chem
. 2018 Jul;
399(12):1363-1374.
PMID: 30044755
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein that binds and escorts the low density lipoprotein receptor (LDLR) into the lysosomal degradation pathway. Prescribed monoclonal antibodies (mAbs) against...
5.
Roubtsova A, Chamberland A, Marcinkiewicz J, Essalmani R, Fazel A, Bergeron J, et al.
J Lipid Res
. 2015 Sep;
56(11):2133-42.
PMID: 26323289
Proprotein convertase subtilisin kexin type 9 (PCSK9), the last member of the family of Proprotein Convertases related to Subtilisin and Kexin, regulates LDL-cholesterol by promoting the endosomal/lysosomal degradation of the...
6.
Butkinaree C, Canuel M, Essalmani R, Poirier S, Benjannet S, Asselin M, et al.
J Biol Chem
. 2015 Jun;
290(30):18609-20.
PMID: 26085104
Amyloid precursor-like protein 2 (APLP2) and sortilin were reported to individually bind the proprotein convertase subtilisin/kexin type 9 (PCSK9) and regulate its activity on the low-density lipoprotein receptor (LDLR). The...
7.
Awan Z, Denis M, Roubtsova A, Essalmani R, Marcinkiewicz J, Awan A, et al.
Angiology
. 2015 Apr;
67(2):157-67.
PMID: 25904765
Background: Given the link between cholesterol and activation of inflammation via interleukin 1β (IL-1β), we tested the effects of IL-1β inhibition on atherosclerotic calcification in mice. Patients with familial hypercholesterolemia...
8.
Wetsel W, Rodriguiz R, Guillemot J, Rousselet E, Essalmani R, Kim I, et al.
Proc Natl Acad Sci U S A
. 2013 Oct;
110(43):17362-7.
PMID: 24101515
PC7 belongs to the proprotein convertase family, whose members are implicated in the cleavage of secretory precursors. The in vivo function of PC7 is unknown. Herein, we find that the...
9.
Denis M, Marcinkiewicz J, Zaid A, Gauthier D, Poirier S, Lazure C, et al.
Circulation
. 2012 Jan;
125(7):894-901.
PMID: 22261195
Background: The proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes independently of its enzymatic activity the degradation of the low-density lipoprotein (LDL) receptor. PCSK9 gain of function in humans leads to...
10.
Rousselet E, Marcinkiewicz J, Kriz J, Zhou A, Hatten M, Prat A, et al.
J Lipid Res
. 2011 Apr;
52(7):1383-91.
PMID: 21518694
Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a major role in cholesterol homeostasis through enhanced degradation of the LDL receptor (LDLR) in liver. As novel inhibitors/silencers of PCSK9 are now...