Michel Chretien
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Explore the profile of Michel Chretien including associated specialties, affiliations and a list of published articles.
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85
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2594
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Recent Articles
1.
Roy A, Chan M, Banadyga L, He S, Zhu W, Chretien M, et al.
Virol J
. 2024 Jan;
21(1):29.
PMID: 38273400
Background: Several in silico studies have determined that quercetin, a plant flavonol, could bind with strong affinity and low free energy to SARS-CoV-2 proteins involved in viral entry and replication,...
2.
Briere R, Emond M, Benhamed A, Blanchard P, Golbon B, Shellenberger J, et al.
Can J Surg
. 2024 Jan;
66(6 Suppl 1):S54-S136.
PMID: 38173057
No abstract available.
3.
Bissonnette S, Lamantia V, Ouimet B, Cyr Y, Devaux M, Rabasa-Lhoret R, et al.
Sci Rep
. 2023 Nov;
13(1):18848.
PMID: 37914804
Elevated plasma numbers of atherogenic apoB-lipoproteins (apoB), mostly as low-density lipoproteins (LDL), predict diabetes risk by unclear mechanisms. Upregulation of the NLRP3 inflammasome/interleukin-1 beta (IL-1β) system in white adipose tissue...
4.
Mbikay M, Chretien M
Front Pharmacol
. 2022 Mar;
13:830205.
PMID: 35308240
Isoquercetin and quercetin are secondary metabolites found in a variety of plants, including edible ones. Isoquercetin is a monoglycosylated derivative of quercetin. When ingested, isoquercetin accumulates more than quercetin in...
5.
Mbikay M, Chretien M
Biochem Cell Biol
. 2022 Mar;
100(3):189-198.
PMID: 35263196
Proprotein Convertase Subtilisin/Kexin-type 9 (PCSK9) is a circulating negative regulator of hepatic low-density lipoprotein receptor (LDLR), which clears cholesterol from blood. Gain-of-function genetic mutations that amplify PCSK9 activity have been...
6.
Cyr Y, Lamantia V, Bissonnette S, Burnette M, Besse-Patin A, Demers A, et al.
Physiol Rep
. 2021 Feb;
9(3):e14721.
PMID: 33527668
Background: LDL-cholesterol lowering variants that upregulate receptor uptake of LDL, such as in PCSK9 and HMGCR, are associated with diabetes via unclear mechanisms. Activation of the NLRP3 inflammasome/interleukin-1 beta (IL-1β)...
7.
Lebeau P, Wassef H, Byun J, Platko K, Ason B, Jackson S, et al.
J Clin Invest
. 2020 Nov;
131(2).
PMID: 33211673
Individuals harboring the loss-of-function (LOF) proprotein convertase subtilisin/kexin type 9 Gln152His variation (PCSK9Q152H) have low circulating low-density lipoprotein cholesterol levels and are therefore protected against cardiovascular disease (CVD). This uncleavable...
8.
Cyr Y, Bissonnette S, Lamantia V, Wassef H, Loizon E, Ngo Sock E, et al.
Obesity (Silver Spring)
. 2020 Oct;
28(12):2357-2367.
PMID: 33043593
Objective: Human conditions with upregulated receptor uptake of low-density lipoproteins (LDL) are associated with diabetes risk, the reasons for which remain unexplored. LDL induce metabolic dysfunction in murine adipocytes. Thus,...
9.
Fedoryak O, Arama C, Diarra I, Kouriba B, Chretien M, Mbikay M
Can J Infect Dis Med Microbiol
. 2020 Oct;
2020:9340480.
PMID: 33029265
Recent evidence suggests that proprotein convertase subtilisin/kexin type 9 (PCSK9), a downmodulator of cellular uptake of blood cholesterol, also negatively impacts host immune response to microbial infection. In this study,...
10.
Mbikay M, Mayne J, Chretien M
Lipids Health Dis
. 2020 Feb;
19(1):17.
PMID: 32014013
Soluble low-density lipoprotein receptor (sLDLR) is the circulating ectodomain of transmembrane LDLR. Its blood level strongly correlates with that of triglycerides (TG). This correlation has eluded satisfactory explanation. Hypertriglyceridemia and...