Jose Luis Vela
Overview
Explore the profile of Jose Luis Vela including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
755
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Recent Articles
11.
Kinjo Y, Illarionov P, Vela J, Pei B, Girardi E, Li X, et al.
Nat Immunol
. 2011 Sep;
12(10):966-74.
PMID: 21892173
Natural killer T cells (NKT cells) recognize glycolipid antigens presented by CD1d. These cells express an evolutionarily conserved, invariant T cell antigen receptor (TCR), but the forces that drive TCR...
12.
Duong B, Ota T, Ait-Azzouzene D, Aoki-Ota M, Vela J, Huber C, et al.
J Immunol
. 2010 Mar;
184(8):4143-58.
PMID: 20231687
Transitional B cells turn over rapidly in vivo and are sensitive to apoptosis upon BCR ligation in vitro. However, little direct evidence addresses their tolerance sensitivity in vivo. A key...
13.
Duong B, Tian H, Ota T, Completo G, Han S, Vela J, et al.
J Exp Med
. 2009 Dec;
207(1):173-87.
PMID: 20038598
Autoreactive B lymphocytes first encountering self-antigens in peripheral tissues are normally regulated by induction of anergy or apoptosis. According to the "two-signal" model, antigen recognition alone should render B cells...
14.
Vela J, Ait-Azzouzene D, Duong B, Ota T, Nemazee D
Immunity
. 2008 Feb;
28(2):161-70.
PMID: 18261939
The recombining sequence (RS) of mouse and its human equivalent, the immunoglobulin (Ig) kappa deleting element (IGKDE), are sequences found at the 3' end of the Ig kappa locus (Igk)...
15.
Verkoczy L, Duong B, Skog P, Ait-Azzouzene D, Puri K, Vela J, et al.
J Immunol
. 2007 May;
178(10):6332-41.
PMID: 17475862
PI3K plays key roles in cell growth, differentiation, and survival by generating the second messenger phosphatidylinositol-(3,4,5)-trisphosphate (PIP3). PIP3 activates numerous enzymes, in part by recruiting them from the cytosol to...
16.
17.
Ait-Azzouzene D, Verkoczy L, Peters J, Gavin A, Skog P, Vela J, et al.
J Exp Med
. 2005 Mar;
201(5):817-28.
PMID: 15738053
Understanding immune tolerance mechanisms is a major goal of immunology research, but mechanistic studies have generally required the use of mouse models carrying untargeted or targeted antigen receptor transgenes, which...
18.
Gavin A, Ait-Azzouzene D, Martensson A, Duong B, Verkoczy L, Vela J, et al.
Keio J Med
. 2004 Oct;
53(3):151-8.
PMID: 15477728
This lecture discusses two interrelated topics, B cell tolerance in the peripheral immune system and BAFF. Using the 3-83 antibody transgenic mouse bred to mice carrying cognate antigen in the...