David Nemazee
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Explore the profile of David Nemazee including associated specialties, affiliations and a list of published articles.
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119
Citations
6953
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Recent Articles
1.
Faliti C, Mesina M, Choi J, Belanger S, Marshall M, Tipton C, et al.
Immunity
. 2024 Nov;
57(12):2772-2789.e8.
PMID: 39612915
During antigen-driven responses, B cells can differentiate at extra-follicular (EF) sites or initiate germinal centers (GCs) in processes that involve interactions with T cells. Here, we examined the roles of...
2.
Structural and mechanistic insights into disease-associated endolysosomal exonucleases PLD3 and PLD4
Yuan M, Peng L, Huang D, Gavin A, Luan F, Tran J, et al.
Structure
. 2024 Mar;
32(6):766-779.e7.
PMID: 38537643
Endolysosomal exonucleases PLD3 and PLD4 (phospholipases D3 and D4) are associated with autoinflammatory and autoimmune diseases. We report structures of these enzymes, and the molecular basis of their catalysis. The...
3.
Structural and mechanistic insights into disease-associated endolysosomal exonucleases PLD3 and PLD4
Yuan M, Peng L, Huang D, Gavin A, Luan F, Tran J, et al.
bioRxiv
. 2023 Dec;
PMID: 38045427
Endolysosomal exonucleases PLD3 and PLD4 (phospholipases D3 and D4) are associated with autoinflammatory and autoimmune diseases. We report structures of these enzymes, and the molecular basis of their catalysis. The...
4.
Zhao F, Yuan M, Keating C, Shaabani N, Limbo O, Joyce C, et al.
Sci Signal
. 2023 Aug;
16(798):eabk3516.
PMID: 37582161
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) underscores the need for strategies to rapidly develop neutralizing monoclonal antibodies that can function as prophylactic and therapeutic agents and...
5.
Gavin A, Blane T, Thinnes T, Gerlt E, Marshak-Rothstein A, Huang D, et al.
Immunohorizons
. 2023 Aug;
7(8):577-586.
PMID: 37555846
Phospholipase D4 (PLD4) is an endolysosomal exonuclease of ssRNA and ssDNA, rather than a phospholipase as its name suggests. Human polymorphisms in the PLD4 gene have been linked by genome-wide...
6.
Dacon C, Peng L, Lin T, Tucker C, Lee C, Cong Y, et al.
Cell Host Microbe
. 2023 Jun;
31(6):1071-1072.
PMID: 37321165
No abstract available.
7.
Bale S, Yang L, Alirezaei M, Wilson R, Ota T, Doyle E, et al.
Front Immunol
. 2023 Jun;
14:1180959.
PMID: 37283743
An effective HIV vaccine likely requires the elicitation of neutralizing antibodies (NAbs) against multiple HIV-1 clades. The recently developed cleavage-independent native flexibly linked (NFL) envelope (Env) trimers exhibit well-ordered conformation...
8.
Song G, Yuan M, Liu H, Capozzola T, Lin R, Torres J, et al.
bioRxiv
. 2023 May;
PMID: 37162858
Developing broad coronavirus vaccines requires identifying and understanding the molecular basis of broadly neutralizing antibody (bnAb) spike sites. In our previous work, we identified sarbecovirus spike RBD group 1 and...
9.
Hurtado J, Flynn C, Lee J, Salcedo E, Cottrell C, Skog P, et al.
Front Cell Infect Microbiol
. 2023 Mar;
12():962945.
PMID: 36968243
The ability to efficiently isolate antigen-specific B cells in high throughput will greatly accelerate the discovery of therapeutic monoclonal antibodies (mAbs) and catalyze rational vaccine development. Traditional mAb discovery is...
10.
Zhou P, Song G, Liu H, Yuan M, He W, Beutler N, et al.
Immunity
. 2023 Mar;
56(3):669-686.e7.
PMID: 36889306
Pan-betacoronavirus neutralizing antibodies may hold the key to developing broadly protective vaccines against novel pandemic coronaviruses and to more effectively respond to SARS-CoV-2 variants. The emergence of Omicron and subvariants...