Jose Luis Vela
Overview
Explore the profile of Jose Luis Vela including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
755
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Recent Articles
1.
Sidney J, Vela J, Friedrich D, Kolla R, von Herrath M, Wesley J, et al.
BMC Immunol
. 2018 Mar;
19(1):12.
PMID: 29562882
Background: Type 1 diabetes (T1D) is thought to be an autoimmune disease driven by anti-islet antigen responses and mediated by T-cells. Recent published data suggests that T-cell reactivity to modified...
2.
Gronholm J, Pagni P, Pham M, Gibson C, Macomber P, Vela J, et al.
Diabetologia
. 2017 Apr;
60(8):1475-1482.
PMID: 28455654
Aims/hypothesis: Insulin is widely considered to be a driver antigen in type 1 diabetes in humans and in mouse models of the disease. Therefore, insulin or insulin analogues are candidates...
3.
Pham M, Gibson C, Ryden A, Perdue N, Boursalian T, Pagni P, et al.
Clin Immunol
. 2016 Jan;
164:28-33.
PMID: 26821303
Studies have shown oral insulin prevents type 1 diabetes (T1D) in mouse models, however human trials were inconclusive. We tested the ability of different insulins to prevent T1D in non-obese...
4.
Pham M, von Herrath M, Vela J
Front Immunol
. 2016 Jan;
6:651.
PMID: 26793191
Regulatory T cells (Tregs) play an important role in preventing effector T-cell (Teff) targeting of self-antigens that can lead to tissue destruction in autoimmune settings, including type 1 diabetes (T1D)....
5.
Pei B, Zhao M, Miller B, Vela J, Bruinsma M, Virgin H, et al.
J Immunol
. 2015 May;
194(12):5872-84.
PMID: 25926673
Autophagy regulates cell differentiation, proliferation, and survival in multiple cell types, including cells of the immune system. In this study, we examined the effects of a disruption of autophagy on...
6.
Ito Y, Vela J, Matsumura F, Hoshino H, Tyznik A, Lee H, et al.
PLoS One
. 2013 Dec;
8(12):e78191.
PMID: 24312443
Approximately 10-15% of individuals infected with Helicobacter pylori will develop ulcer disease (gastric or duodenal ulcer), while most people infected with H. pylori will be asymptomatic. The majority of infected...
7.
Kawasaki N, Vela J, Nycholat C, Rademacher C, Khurana A, van Rooijen N, et al.
Proc Natl Acad Sci U S A
. 2013 Apr;
110(19):7826-31.
PMID: 23610394
Invariant natural killer T (iNKT) cells induce a protective immune response triggered by foreign glycolipid antigens bound to CD1d on antigen-presenting cells (APCs). A limitation of using glycolipid antigens to...
8.
Shui J, Larange A, Kim G, Vela J, Zahner S, Cheroutre H, et al.
Nature
. 2012 Jul;
488(7410):222-5.
PMID: 22801499
The herpes virus entry mediator (HVEM), a member of the tumour-necrosis factor receptor family, has diverse functions, augmenting or inhibiting the immune response. HVEM was recently reported as a colitis...
9.
Pei B, Vela J, Zajonc D, Kronenberg M
Ann N Y Acad Sci
. 2012 Feb;
1253:68-79.
PMID: 22352829
Natural killer T (NKT) cells are a T cell subpopulation that were named originally based on coexpression of receptors found on natural killer (NK) cells, cells of the innate immune...
10.
Duong B, Ota T, Aoki-Ota M, Cooper A, Ait-Azzouzene D, Vela J, et al.
J Immunol
. 2011 Nov;
187(11):5596-605.
PMID: 22043016
To analyze B lymphocyte central tolerance in a polyclonal immune system, mice were engineered to express a superantigen reactive to IgM of allotype b (IgM(b)). IgM(b/b) mice carrying superantigen were...