Jordan L Meier
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Explore the profile of Jordan L Meier including associated specialties, affiliations and a list of published articles.
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97
Citations
2197
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Recent Articles
21.
Perez M, Nance K, Bak D, Thalalla Gamage S, Najera S, Conte A, et al.
ACS Chem Biol
. 2022 Oct;
17(10):2789-2800.
PMID: 36190452
Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is a cancer predisposition syndrome driven by mutation of the tumor suppressor fumarate hydratase (FH). Inactivation of FH causes accumulation of the electrophilic...
22.
Thalalla Gamage S, Bortolin-Cavaille M, Link C, Bryson K, Sas-Chen A, Schwartz S, et al.
RNA
. 2022 Sep;
28(12):1582-1596.
PMID: 36127124
N4-acetylcytidine (acC) is an RNA nucleobase found in all domains of life. The establishment of acC in helix 45 (h45) of human 18S ribosomal RNA (rRNA) requires the combined activity...
23.
Dibble C, Barritt S, Perry G, Lien E, Geck R, DuBois-Coyne S, et al.
Nature
. 2022 Jul;
608(7921):192-198.
PMID: 35896750
In response to hormones and growth factors, the class I phosphoinositide-3-kinase (PI3K) signalling network functions as a major regulator of metabolism and growth, governing cellular nutrient uptake, energy generation, reducing...
24.
Bortolin-Cavaille M, Quillien A, Thalalla Gamage S, Thomas J, Sas-Chen A, Sharma S, et al.
Nucleic Acids Res
. 2022 Jun;
50(11):6284-6299.
PMID: 35648437
NAT10 is an essential enzyme that catalyzes N4-acetylcytidine (ac4C) in eukaryotic transfer RNA and 18S ribosomal RNA. Recent studies suggested that rRNA acetylation is dependent on SNORD13, a box C/D...
25.
Doan M, Neinast M, Varner E, Bedi Jr K, Bartee D, Jiang H, et al.
J Lipid Res
. 2022 May;
63(6):100224.
PMID: 35568254
Anabolic metabolism of carbon in mammals is mediated via the one- and two-carbon carriers S-adenosyl methionine and acetyl-coenzyme A. In contrast, anabolic metabolism of three-carbon units via propionate has not...
26.
Trub A, Wagner G, Anderson K, Crown S, Zhang G, Thompson J, et al.
Nat Commun
. 2022 May;
13(1):2542.
PMID: 35538051
Statins are a class of drug widely prescribed for the prevention of cardiovascular disease, with pleiotropic cellular effects. Statins inhibit HMG-CoA reductase (HMGCR), which converts the metabolite HMG-CoA into mevalonate....
27.
Link C, Thalalla Gamage S, Gallimore D, Kopajtich R, Evans C, Nance S, et al.
Biochemistry
. 2022 Mar;
61(7):535-544.
PMID: 35285626
Chemical modification of cytidine in noncoding RNAs plays a key role in regulating translation and disease. However, the distribution and dynamics of many of these modifications remain unknown due to...
28.
Muller S, Ackloo S, Al Chawaf A, Al-Lazikani B, Antolin A, Baell J, et al.
RSC Med Chem
. 2022 Feb;
13(1):13-21.
PMID: 35211674
Twenty years after the publication of the first draft of the human genome, our knowledge of the human proteome is still fragmented. The challenge of translating the wealth of new...
29.
Nance K, Thalalla Gamage S, Alam M, Yang A, Levy M, Link C, et al.
Cell Chem Biol
. 2022 Feb;
29(2):312-320.e7.
PMID: 35180432
Synthetic messenger RNA (mRNA) is an emerging therapeutic platform with important applications in oncology and infectious disease. Effective mRNA medicines must be translated by the ribosome but not trigger a...
30.
Bartee D, Nance K, Meier J
J Am Chem Soc
. 2022 Feb;
144(8):3487-3496.
PMID: 35172571
-Acetylcytidine (ac4C) is a post-transcriptional modification of RNA that is conserved across all domains of life. All characterized sites of ac4C in eukaryotic RNA occur in the central nucleotide of...