Jordan L Meier
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Explore the profile of Jordan L Meier including associated specialties, affiliations and a list of published articles.
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97
Citations
2197
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Recent Articles
11.
Fitzsimmons C, Mandler M, Lunger J, Chan D, Maligireddy S, Schmiechen A, et al.
NAR Cancer
. 2024 Feb;
6(1):zcae004.
PMID: 38328795
Metabolic reprogramming is a hallmark of cancer that facilitates changes in many adaptive biological processes. Mutations in the tricarboxylic acid cycle enzyme fumarate hydratase (FH) lead to fumarate accumulation and...
12.
Thalalla Gamage S, Howpay Manage S, Chu T, Meier J
Acc Chem Res
. 2024 Jan;
57(3):338-348.
PMID: 38226431
Acetylation plays a critical role in regulating eukaryotic transcription via the modification of histones. Beyond this well-documented function, a less explored biological frontier is the potential for acetylation to modify...
13.
Crawford M, Tripu D, Barritt S, Jing Y, Gallimore D, Kales S, et al.
ACS Chem Biol
. 2023 Sep;
18(10):2249-2258.
PMID: 37737090
The human acetyltransferase paralogues EP300 and CREBBP are master regulators of lysine acetylation whose activity has been implicated in various cancers. In the half-decade since the first drug-like inhibitors of...
14.
Crooks D, Cawthon G, Fitzsimmons C, Perez M, Ricketts C, Vocke C, et al.
Hum Mol Genet
. 2023 Aug;
32(22):3135-3145.
PMID: 37561409
Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is an autosomal dominant condition characterized by the development of cutaneous and uterine leiomyomas and risk for development of an aggressive form of...
15.
Lieberman W, Brown Z, Kantner D, Jing Y, Megill E, Evans N, et al.
J Am Chem Soc
. 2023 Jul;
145(30):16899-16905.
PMID: 37486078
Chemoproteomic profiling is a powerful approach to define the selectivity of small molecules and endogenous metabolites with the human proteome. In addition to mechanistic studies, proteome specificity profiling also has...
16.
Crawford M, Tripu D, Barritt S, Jing Y, Gallimore D, Kales S, et al.
bioRxiv
. 2023 Jun;
PMID: 37292747
The human acetyltransferase paralogs EP300 and CREBBP are master regulators of lysine acetylation whose activity has been implicated in various cancers. In the half-decade since the first drug-like inhibitors of...
17.
18.
Head P, Meier J, Venditti C
J Inherit Metab Dis
. 2023 Apr;
46(3):436-449.
PMID: 37078237
Methylmalonic acidemia (MMA) is a severe inborn error of metabolism that is characterized by pleiotropic metabolic perturbations and multiorgan pathology. Treatment options are limited and non-curative as the underlying causative...
19.
20.
Dahlin J, Hua B, Zucconi B, Nelson Jr S, Singh S, Carpenter A, et al.
Nat Commun
. 2023 Mar;
14(1):1364.
PMID: 36914634
Robust, generalizable approaches to identify compounds efficiently with undesirable mechanisms of action in complex cellular assays remain elusive. Such a process would be useful for hit triage during high-throughput screening...