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Jonathan R Keller

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Articles 56
Citations 1783
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Recent Articles
1.
Singh S, Sarkar T, Jakubison B, Gadomski S, Spradlin A, Gudmundsson K, et al.
Front Immunol . 2022 Aug; 13:934624. PMID: 35990659
Adult mammalian hematopoiesis is a dynamic cellular process that provides a continuous supply of myeloid, lymphoid, erythroid/megakaryocyte cells for host survival. This process is sustained by regulating hematopoietic stem cells...
2.
Jakubison B, Sarkar T, Gudmundsson K, Singh S, Sun L, Morris H, et al.
J Clin Invest . 2022 Jul; 132(13). PMID: 35775482
Defining mechanism(s) that maintain tissue stem quiescence is important for improving tissue regeneration, cell therapies, aging, and cancer. We report here that genetic ablation of Id2 in adult hematopoietic stem...
3.
Mishra A, Hartford S, Sahu S, Klarmann K, Chittela R, Biswas K, et al.
Nat Commun . 2022 Apr; 13(1):1751. PMID: 35365640
The interaction between tumor suppressor BRCA2 and DSS1 is essential for RAD51 recruitment and repair of DNA double stand breaks (DSBs) by homologous recombination (HR). We have generated mice with...
4.
Suliman-Lavie R, Title B, Cohen Y, Hamada N, Tal M, Tal N, et al.
Nat Commun . 2021 Jun; 12(1):3874. PMID: 34140510
No abstract available.
5.
Parthibane V, Lin J, Acharya D, Abimannan T, Srideshikan S, Klarmann K, et al.
J Biol Chem . 2021 Mar; 296:100491. PMID: 33662400
Serine palmitoyltransferase complex (SPT) mediates the first and rate-limiting step in the de novo sphingolipid biosynthetic pathway. The larger subunits SPTLC1 and SPTLC2/SPTLC3 together form the catalytic core while a...
6.
Suliman-Lavie R, Title B, Cohen Y, Hamada N, Tal M, Tal N, et al.
Nat Commun . 2020 Nov; 11(1):5836. PMID: 33203851
Several genes implicated in autism spectrum disorder (ASD) are chromatin regulators, including POGZ. The cellular and molecular mechanisms leading to ASD impaired social and cognitive behavior are unclear. Animal models...
7.
Singh S, Jakubison B, Keller J
Curr Opin Hematol . 2020 May; 27(4):225-231. PMID: 32398455
Purpose Of Review: Hematopoietic stem cells (HSCs) are defined by their ability to self-renew and differentiate to replenish all blood lineages throughout adult life. Under homeostasis, the majority of HSCs...
8.
Nakaya M, Gudmundsson K, Komiya Y, Keller J, Habas R, Yamaguchi T, et al.
PLoS One . 2020 May; 15(4):e0232025. PMID: 32353019
The actin cytoskeleton plays a central role in establishing cell polarity and shape during embryonic morphogenesis. Daam1, a member of the Formin family of actin cytoskeleton regulators, is a Dvl2-binding...
9.
Gadomski S, Singh S, Singh S, Sarkar T, Klarmann K, Berenschot M, et al.
Cell Rep . 2020 Apr; 31(4):107572. PMID: 32348770
Investigating mechanisms that regulate endothelial cell (EC) growth and survival is important for understanding EC homeostasis and how ECs maintain stem cell niches. We report here that targeted loss of...
10.
Zhong C, Zheng M, Cui K, Martins A, Hu G, Li D, et al.
Immunity . 2019 Dec; 52(1):83-95.e4. PMID: 31882362
Lymphoid tissue inducer (LTi) cells are regarded as a subset of innate lymphoid cells (ILCs). However, these cells are not derived from the ILC common progenitor, which generates other ILC...