Differential Expression of the Transcription Factor GATA3 Specifies Lineage and Functions of Innate Lymphoid Cells

Overview

Journal Immunity

Publisher Cell Press

Specialty Allergy & Immunology

Date 2019 Dec 29

PMID 31882362

Citations 45

Authors

Chao Zhong

Mingzhu Zheng

Kairong Cui

Andrew J Martins

Gangqing Hu

Dan Li

Lino Tessarollo

Serguei Kozlov

Jonathan R Keller

John S Tsang

Keji Zhao

Jinfang Zhu

Affiliations

Soon will be listed here.

Abstract

Lymphoid tissue inducer (LTi) cells are regarded as a subset of innate lymphoid cells (ILCs). However, these cells are not derived from the ILC common progenitor, which generates other ILC subsets and is defined by the expression of the transcription factor PLZF. Here, we examined transcription factor(s) determining the fate of LTi progenitors versus non-LTi ILC progenitors. Conditional deletion of Gata3 resulted in the loss of PLZF non-LTi progenitors but not the LTi progenitors that expressed the transcription factor RORγt. Consistently, PLZF non-LTi progenitors expressed high amounts of GATA3, whereas GATA3 expression was low in RORγt LTi progenitors. The generation of both progenitors required the transcriptional regulator Id2, which defines the common helper-like innate lymphoid progenitor (ChILP), but not cytokine signaling. Nevertheless, low GATA3 expression was necessary for the generation of functionally mature LTi cells. Thus, differential expression of GATA3 determines the fates and functions of distinct ILC progenitors.

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