Jonathan K Dozier
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Explore the profile of Jonathan K Dozier including associated specialties, affiliations and a list of published articles.
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12
Citations
362
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Recent Articles
1.
Mohammed I, Hampton S, Ashall L, Hildebrandt E, Kutlik R, Manandhar S, et al.
Bioorg Med Chem
. 2015 Dec;
24(2):160-78.
PMID: 26706114
Ras converting enzyme 1 (Rce1) is an endoprotease that catalyzes processing of the C-terminus of Ras protein by removing -aaX from the CaaX motif. The activity of Rce1 is crucial...
2.
Dozier J, Distefano M
Int J Mol Sci
. 2015 Oct;
16(10):25831-64.
PMID: 26516849
The use of proteins as therapeutics has a long history and is becoming ever more common in modern medicine. While the number of protein-based drugs is growing every year, significant...
3.
Dozier J, Khatwani S, Wollack J, Wang Y, Schmidt-Dannert C, Distefano M
Bioconjug Chem
. 2014 Jun;
25(7):1203-12.
PMID: 24946229
Creating covalent protein conjugates is an active area of research due to the wide range of uses for protein conjugates spanning everything from biological studies to protein therapeutics. Protein Farnesyltransferase...
4.
Wollack J, Monson B, Dozier J, Dalluge J, Poss K, Hilderbrand S, et al.
Chem Biol Drug Des
. 2014 Jun;
84(2):140-7.
PMID: 24899362
There is a growing library of functionalized non-natural substrates for the enzyme protein farnesyltransferase (PFTase). PFTase covalently attaches these functionalized non-natural substrates to proteins ending in the sequence CAAX, where...
5.
Wang Y, Dozier J, Beese L, Distefano M
ACS Chem Biol
. 2014 May;
9(8):1726-35.
PMID: 24841702
Protein farnesytransferase (PFTase) catalyzes the farnesylation of proteins with a carboxy-terminal tetrapeptide sequence denoted as a Ca1a2X box. To explore the specificity of this enzyme, an important therapeutic target, solid-phase...
6.
Tolstyka Z, Richardson W, Bat E, Stevens C, Parra D, Dozier J, et al.
Chembiochem
. 2013 Oct;
14(18):2464-71.
PMID: 24166802
Herein, a combination of microcontact printing of functionalized alkanethiols and site-specific modification of proteins is utilized to chemoselectively immobilize proteins onto gold surfaces, either by oxime- or copper-catalyzed alkyne-azide click...
7.
Mahmoodi M, Rashidian M, Dozier J, Distefano M
Curr Protoc Chem Biol
. 2013 Jul;
5(2):89-109.
PMID: 23839992
In a facile and potentially general method for protein modification at the C-terminus, aldehyde-modified proteins, obtained from enzymatic protein prenylation, react rapidly with hydrazide and aminooxy surfaces and fluorophores at...
8.
Rashidian M, Dozier J, Distefano M
Bioconjug Chem
. 2013 Jul;
24(8):1277-94.
PMID: 23837885
Site-specific modification of proteins is a major challenge in modern chemical biology due to the large number of reactive functional groups typically present in polypeptides. Because of its importance in...
9.
Rashidian M, Mahmoodi M, Shah R, Dozier J, Wagner C, Distefano M
Bioconjug Chem
. 2013 Feb;
24(3):333-42.
PMID: 23425124
Imine-based reactions are useful for a wide range of bioconjugation applications. Although aniline is known to catalyze the oxime ligation reaction under physiological conditions, it suffers from slow reaction kinetics,...
10.
Dozier J, Distefano M
Anal Biochem
. 2011 Nov;
421(1):158-63.
PMID: 22085443
Farnesyl diphosphate synthase (FDPS) catalyzes the conversion of isopentenyl diphosphate and dimethylallyl diphosphate to farnesyl diphosphate, a crucial metabolic intermediate in the synthesis of cholesterol, ubiquinone, and prenylated proteins; consequently,...