James W Wollack
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Explore the profile of James W Wollack including associated specialties, affiliations and a list of published articles.
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9
Citations
117
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Recent Articles
1.
Auger S, Venkatachalapathy S, Suazo K, Wang Y, Sarkis A, Bernhagen K, et al.
Bioconjug Chem
. 2024 Apr;
35(7):922-933.
PMID: 38654427
Bioorthogonal chemistry has gained widespread use in the study of many biological systems of interest, including protein prenylation. Prenylation is a post-translational modification, in which one or two 15- or...
2.
Janzen D, Crepeau L, Hageseth B, Wollack J
Acta Crystallogr Sect E Struct Rep Online
. 2014 Sep;
70(Pt 8):o859.
PMID: 25249909
In the title compound, C13H10N2O4, the nitro groups are twisted significantly relative to the benzene rings [dihedral angles = 16.64 (18) and 28.02 (11)°]. The benzene groups are nearly perpendicular...
3.
Dozier J, Khatwani S, Wollack J, Wang Y, Schmidt-Dannert C, Distefano M
Bioconjug Chem
. 2014 Jun;
25(7):1203-12.
PMID: 24946229
Creating covalent protein conjugates is an active area of research due to the wide range of uses for protein conjugates spanning everything from biological studies to protein therapeutics. Protein Farnesyltransferase...
4.
Wollack J, Monson B, Dozier J, Dalluge J, Poss K, Hilderbrand S, et al.
Chem Biol Drug Des
. 2014 Jun;
84(2):140-7.
PMID: 24899362
There is a growing library of functionalized non-natural substrates for the enzyme protein farnesyltransferase (PFTase). PFTase covalently attaches these functionalized non-natural substrates to proteins ending in the sequence CAAX, where...
5.
Wollack J, Zeliadt N, Ochocki J, Mullen D, Barany G, Wattenberg E, et al.
Bioorg Med Chem Lett
. 2009 Dec;
20(1):161-3.
PMID: 20004573
Cell penetrating peptides are useful delivery tools for introducing molecules of interest into cells. A new class of cell penetrating molecules has been recently reported-cell penetrating, prenylated peptides. In this...
6.
Wollack J, Silverman J, Petzold C, Mougous J, Distefano M
Chembiochem
. 2009 Oct;
10(18):2934-43.
PMID: 19856367
Recently a number of nonnatural prenyl groups containing alkynes and azides have been developed as handles to perform click chemistry on proteins and peptides ending in the sequence "CAAX", where...
7.
Wollack J, Zeliadt N, Mullen D, Amundson G, Geier S, Falkum S, et al.
J Am Chem Soc
. 2009 May;
131(21):7293-303.
PMID: 19425596
Protein prenylation is a common post-translational modification present in eukaryotic cells. Many key proteins involved in signal transduction pathways are prenylated, and inhibition of prenylation can be useful as a...
8.
Chung J, Wollack J, Hovlid M, Okesli A, Chen Y, Mueller J, et al.
Anal Biochem
. 2008 Oct;
386(1):1-8.
PMID: 18834849
Although protein prenylation is widely studied, there are few good methods for isolating prenylated proteins from their nonprenylated relatives. We report that crosslinked agarose (e.g., Sepharose) chromatography medium that has...
9.
Duckworth B, Chen Y, Wollack J, Sham Y, Mueller J, Taton T, et al.
Angew Chem Int Ed Engl
. 2007 Oct;
46(46):8819-22.
PMID: 17935099
No abstract available.