Jonathan Hoggatt
Overview
Explore the profile of Jonathan Hoggatt including associated specialties, affiliations and a list of published articles.
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Articles
32
Citations
1452
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Recent Articles
21.
Zhao W, Breese E, Bowers A, Hoggatt J, Pelus L, Broxmeyer H, et al.
PLoS One
. 2013 May;
8(4):e61123.
PMID: 23630580
Significant insight into the signaling pathways leading to activation of the Rel transcription factor family, collectively termed NF-κB, has been gained. Less well understood is how subsets of NF-κB-dependent genes...
22.
Hoggatt J, Mohammad K, Singh P, Hoggatt A, Chitteti B, Speth J, et al.
Nature
. 2013 Mar;
495(7441):365-9.
PMID: 23485965
To maintain lifelong production of blood cells, haematopoietic stem cells (HSCs) are tightly regulated by inherent programs and extrinsic regulatory signals received from their microenvironmental niche. Long-term repopulating HSCs reside...
23.
Hoggatt J, Singh P, Stilger K, Plett P, Sampson C, Chua H, et al.
Blood Cells Mol Dis
. 2012 Dec;
50(3):147-53.
PMID: 23206586
While high dose total body irradiation (TBI) is used therapeutically, the proliferation of nuclear weapons, increasing use of nuclear power, and worldwide radical terrorism underscore the need to develop countermeasures...
24.
Broxmeyer H, Hoggatt J, OLeary H, Mantel C, Chitteti B, Cooper S, et al.
Nat Med
. 2012 Nov;
18(12):1786-96.
PMID: 23160239
Enhancement of hematopoietic recovery after radiation, chemotherapy, or hematopoietic stem cell (HSC) transplantation is clinically relevant. Dipeptidylpeptidase (DPP4) cleaves a wide variety of substrates, including the chemokine stromal cell-derived factor-1...
25.
Hoggatt J, Scadden D
J Clin Invest
. 2012 Sep;
122(9):3029-34.
PMID: 22945635
Stem cells are the critical unit affecting tissue maintenance, regeneration, and repair, with particular relevance to the tissues with high cell turnover. Stem cell regulation accommodates the conflicting needs of...
26.
Hoggatt J, Pelus L
Methods Mol Biol
. 2012 Aug;
904:49-67.
PMID: 22890921
Hematopoietic stem and progenitor mobilization has revolutionized the field of hematopoietic transplantation. Currently, hematopoietic grafts acquired from the peripheral blood of patients or donors treated with granulocyte-colony stimulating factor (G-CSF)...
27.
Singh P, Hoggatt J, Hu P, Speth J, Fukuda S, Breyer R, et al.
Blood
. 2011 Nov;
119(7):1671-82.
PMID: 22110249
Dendritic cell (DC) homeostasis, like all mature blood cells, is maintained via hierarchal generation from hematopoietic precursors; however, little is known about the regulatory mechanisms governing DC generation. Here, we...
28.
Pelus L, Hoggatt J
Prostaglandins Other Lipid Mediat
. 2011 Jul;
96(1-4):3-9.
PMID: 21722751
Eicosanoids have been implicated in the physiological regulation of hematopoiesis with pleiotropic effects on hematopoietic stem cells and various classes of lineage restricted progenitor cells. Herein we review the effects...
29.
Hoggatt J, Pelus L
Curr Opin Hematol
. 2011 May;
18(4):231-8.
PMID: 21537168
Purpose Of Review: Blood cell production is maintained by hematopoietic stem cells (HSCs) that reside in specialized niches within bone marrow. Treatment with granulocyte-colony stimulating factor (G-CSF) causes HSC egress...
30.
Hoggatt J, Pelus L
Stem Cell Res Ther
. 2011 Mar;
2(2):13.
PMID: 21418553
The vast majority of hematopoietic stem cells (HSCs) reside in specialized niches within the bone marrow during steady state, maintaining lifelong blood cell production. A small number of HSCs normally...