Jonathan Hoggatt
Overview
Explore the profile of Jonathan Hoggatt including associated specialties, affiliations and a list of published articles.
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32
Citations
1452
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Recent Articles
1.
Chen C, Vander Kooi A, Cavedon A, Cai X, Hoggatt J, Martini P, et al.
Mol Ther Nucleic Acids
. 2023 Nov;
34:102043.
PMID: 37920545
Development of factor VIII (FVIII) inhibitors is a serious complication in the treatment of hemophilia A (HemA) patients. In clinical trials, anti-CD3 antibody therapy effectively modulates the immune response of...
2.
Hoggatt J, Pelus L
Methods Mol Biol
. 2022 Oct;
2567:3-7.
PMID: 36255691
Hematopoietic stem cells (HSCs) support the lifelong production of hundreds of billions of blood cells per day. This unique, incredible ability of HSCs also creates an incredible therapeutic potential for...
3.
Menendez-Gonzalez J, Hoggatt J
Stem Cell Rev Rep
. 2021 Oct;
17(6):1939-1953.
PMID: 34661830
Hematopoietic stem cells naturally traffic out of their bone marrow niches into the peripheral blood. This natural trafficking process can be enhanced with numerous pharmacologic agents - a process termed...
4.
Patterson A, Liu L, Sampson C, Plett P, Li H, Singh P, et al.
Stem Cell Reports
. 2020 Aug;
15(2):358-373.
PMID: 32735825
Ionizing radiation exposure results in acute and delayed bone marrow suppression. Treatment of mice with 16,16-dimethyl prostaglandin E (dmPGE) prior to lethal ionizing radiation (IR) facilitates survival, but the cellular...
5.
Czechowicz A, Palchaudhuri R, Scheck A, Hu Y, Hoggatt J, Saez B, et al.
Nat Commun
. 2019 Feb;
10(1):617.
PMID: 30728354
Hematopoietic stem cell transplantation (HSCT) is a curative therapy for blood and immune diseases with potential for many settings beyond current standard-of-care. Broad HSCT application is currently precluded largely due...
6.
Hoggatt J, Singh P, Tate T, Chou B, Datari S, Fukuda S, et al.
Cell
. 2017 Dec;
172(1-2):191-204.e10.
PMID: 29224778
Hematopoietic stem cell transplantation is a potential curative therapy for malignant and nonmalignant diseases. Improving the efficiency of stem cell collection and the quality of the cells acquired can broaden...
7.
Singh P, Hoggatt J, Kamocka M, Mohammad K, Saunders M, Li H, et al.
J Clin Invest
. 2017 Nov;
127(12):4527-4540.
PMID: 29130940
Endothelial cells (ECs) are components of the hematopoietic microenvironment and regulate hematopoietic stem and progenitor cell (HSPC) homeostasis. Cytokine treatments that cause HSPC trafficking to peripheral blood are associated with...
8.
Silberstein L, Goncalves K, Kharchenko P, Turcotte R, Kfoury Y, Mercier F, et al.
Cell Stem Cell
. 2016 Aug;
19(4):530-543.
PMID: 27524439
Physiological stem cell function is regulated by secreted factors produced by niche cells. In this study, we describe an unbiased approach based on the differential single-cell gene expression analysis of...
9.
Hoggatt J
Cell
. 2016 Jul;
166(2):263.
PMID: 27419862
Adenosine deaminase (ADA) deficiency results in the accumulation of toxic metabolites that destroy the immune system, causing severe combined immunodeficiency (ADA-SCID), often referred to as the "bubble boy" disease. Strimvelis...
10.
Palchaudhuri R, Saez B, Hoggatt J, Schajnovitz A, Sykes D, Tate T, et al.
Nat Biotechnol
. 2016 Jun;
34(7):738-45.
PMID: 27272386
Hematopoietic stem cell transplantation (HSCT) offers curative therapy for patients with hemoglobinopathies, congenital immunodeficiencies, and other conditions, possibly including AIDS. Autologous HSCT using genetically corrected cells would avoid the risk...