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Jonathan D Wood

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Articles 13
Citations 445
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Recent Articles
1.
Franklin J, Testen A, Mieczkowski P, Hepperla A, Crynen G, Simon J, et al.
bioRxiv . 2024 Aug; PMID: 39149305
In recent years, astrocytes have been increasingly implicated in cellular mechanisms of substance use disorders (SUD). Astrocytes are structurally altered following exposure to drugs of abuse; specifically, astrocytes within the...
2.
Lorente Pons A, Higginbottom A, Cooper-Knock J, Alrafiah A, Alofi E, Kirby J, et al.
J Pathol . 2020 May; 251(3):262-271. PMID: 32391572
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease. The majority of cases are sporadic (sALS), while the most common inherited form is due to C9orf72 mutation (C9ALS). A high burden...
3.
Eachus H, Bright C, Cunliffe V, Placzek M, Wood J, Watt P
Hum Mol Genet . 2017 Mar; 26(11):1992-2005. PMID: 28334933
Psychiatric disorders arise due to an interplay of genetic and environmental factors, including stress. Studies in rodents have shown that mutants for Disrupted-In-Schizophrenia-1 (DISC1), a well-accepted genetic risk factor for...
4.
Boyd P, Cunliffe V, Roy S, Wood J
Biol Open . 2015 Sep; 4(10):1336-43. PMID: 26405049
DISRUPTED-IN-SCHIZOPHRENIA (DISC1) has been one of the most intensively studied genetic risk factors for mental illness since it was discovered through positional mapping of a translocation breakpoint in a large...
5.
Butler R, Wood J, Landers J, Cunliffe V
Dis Model Mech . 2010 Sep; 3(11-12):743-51. PMID: 20829563
Mutations in the SPAST (SPG4) gene, which encodes the microtubule-severing protein spastin, are the most common cause of autosomal dominant hereditary spastic paraplegia (HSP). Following on from previous work in...
6.
Kasher P, De Vos K, Wharton S, Manser C, Bennett E, Bingley M, et al.
J Neurochem . 2009 May; 110(1):34-44. PMID: 19453301
Mutations in spastin are the most common cause of hereditary spastic paraplegia (HSP) but the mechanisms by which mutant spastin induces disease are not clear. Spastin functions to regulate microtubule...
7.
Sato T, Miura M, Yamada M, Yoshida T, Wood J, Yazawa I, et al.
Hum Mol Genet . 2008 Nov; 18(4):723-36. PMID: 19039037
We herein provide a thorough description of new transgenic mouse models for dentatorubral-pallidoluysian atrophy (DRPLA) harboring a single copy of the full-length human mutant DRPLA gene with 76 and 129...
8.
Wood J, Bonath F, Kumar S, Ross C, Cunliffe V
Hum Mol Genet . 2008 Nov; 18(3):391-404. PMID: 18996920
Schizophrenia may arise from subtle abnormalities in brain development due to alterations in the functions of candidate susceptibility genes such as Disrupted-in-schizophrenia 1 (DISC1) and Neuregulin 1 (NRG1). To provide...
9.
Wood J, Landers J, Bingley M, McDermott C, Thomas-McArthur V, Gleadall L, et al.
Hum Mol Genet . 2006 Aug; 15(18):2763-71. PMID: 16893913
Hereditary spastic paraplegia (HSP) is a collection of neurological disorders characterized by developmental failure or degeneration of motor axons in the corticospinal tract and progressive lower limb spasticity. SPG4 mutations...
10.
Tanaka Y, Igarashi S, Nakamura M, Gafni J, Torcassi C, Schilling G, et al.
Neurobiol Dis . 2005 Sep; 21(2):381-91. PMID: 16150600
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder characterized behaviorally by chorea, incoordination, and shortened lifespan and neuropathologically by huntingtin inclusions and neuronal degeneration. In order to facilitate studies...