Stephen B Wharton
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Explore the profile of Stephen B Wharton including associated specialties, affiliations and a list of published articles.
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106
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4595
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Recent Articles
1.
Xia Z, Prescott E, Urbanek A, Wareing H, King M, Olerinyova A, et al.
Nat Commun
. 2024 Jun;
15(1):4695.
PMID: 38824138
Which isoforms of apolipoprotein E (apoE) we inherit determine our risk of developing late-onset Alzheimer's Disease (AD), but the mechanism underlying this link is poorly understood. In particular, the relevance...
2.
Sanders M, Gatt D, Lee V, Wharton S, Bagga V
Brain Spine
. 2024 May;
4:102819.
PMID: 38706801
Introduction: Paediatric cerebellar glioblastoma is an exceptionally rare clinical entity, with very few cases described in the literature. In the majority of reported cases, prognosis is extremely poor, despite surgical...
3.
Almansouri T, Waller R, Wharton S, Heath P, Matthews F, Brayne C, et al.
Int J Mol Sci
. 2024 Apr;
25(8).
PMID: 38674030
Age-associated deep-subcortical white matter lesions (DSCLs) are an independent risk factor for dementia, displaying high levels of CD68 microglia. This study aimed to characterize the transcriptomic profile of microglia in...
4.
Floare M, Wharton S, Simpson J, Aeschlimann D, Hoggard N, Hadjivassiliou M
Brain Commun
. 2024 Mar;
6(2):fcae078.
PMID: 38510211
Gluten sensitivity has long been recognized exclusively for its gastrointestinal involvement; however, more recent research provides evidence for the existence of neurological manifestations that can appear in combination with or...
5.
Rajab M, Taketa T, Wharton S, Wang D
Brain Pathol
. 2024 Feb;
34(4):e13247.
PMID: 38374326
Early diagnosis of dementia diseases, such as Alzheimer's disease, is difficult because of the time and resources needed to perform neuropsychological and pathological assessments. Given the increasing use of machine...
6.
Mistry H, Richardson C, Higginbottom A, Ashford B, Ahamed S, Moore Z, et al.
Neurosci Res
. 2024 Jan;
204:22-33.
PMID: 38278219
Altered cholesterol metabolism is implicated in brain ageing and Alzheimer's disease. We examined whether key genes regulating cholesterol metabolism and levels of brain cholesterol are altered in dementia and Alzheimer's...
7.
Wharton S, Simpson J, Ince P, Richardson C, Merrick R, Matthews F, et al.
Neuropathol Appl Neurobiol
. 2023 Jul;
49(4):e12923.
PMID: 37462105
The epidemiological neuropathology perspective of population and community-based studies allows unbiased assessment of the prevalence of various pathologies and their relationships to late-life dementia. In addition, this approach provides complementary...
8.
Rajab M, Jammeh E, Taketa T, Brayne C, Matthews F, Su L, et al.
Alzheimers Res Ther
. 2023 Mar;
15(1):47.
PMID: 36895019
Although a variety of brain lesions may contribute to the pathological assessment of dementia, the relationship of these lesions to dementia, how they interact and how to quantify them remains...
9.
Nichols E, Merrick R, Hay S, Himali D, Himali J, Hunter S, et al.
Lancet Healthy Longev
. 2023 Mar;
4(3):e115-e125.
PMID: 36870337
Background: Population-based autopsy studies provide valuable insights into the causes of dementia but are limited by sample size and restriction to specific populations. Harmonisation across studies increases statistical power and...
10.
Williamson D, Schwalbe E, Hicks D, Aldinger K, Lindsey J, Crosier S, et al.
Cell Rep
. 2022 Aug;
40(5):111162.
PMID: 35926460
Medulloblastoma is currently subclassified into distinct DNA methylation subgroups/subtypes with particular clinico-molecular features. Using RNA sequencing (RNA-seq) in large, well-annotated cohorts of medulloblastoma, we show that transcriptionally group 3 and...