Jonathan D Gruber
Overview
Explore the profile of Jonathan D Gruber including associated specialties, affiliations and a list of published articles.
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14
Citations
437
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Recent Articles
1.
Metzger B, Yuan D, Gruber J, Duveau F, Wittkopp P
Nature
. 2015 Mar;
521(7552):344-7.
PMID: 25778704
Genetic variation segregating within a species reflects the combined activities of mutation, selection, and genetic drift. In the absence of selection, polymorphisms are expected to be a random subset of...
2.
Duveau F, Metzger B, Gruber J, Mack K, Sood N, Brooks T, et al.
G3 (Bethesda)
. 2014 May;
4(7):1205-16.
PMID: 24789747
Genetic variants identified by mapping are biased toward large phenotypic effects because of methodologic challenges for detecting genetic variants with small phenotypic effects. Recently, bulk segregant analysis combined with next-generation...
3.
Gruber J, Vogel K, Kalay G, Wittkopp P
PLoS Genet
. 2012 Feb;
8(2):e1002497.
PMID: 22346762
Genetic variation within and between species can be shaped by population-level processes and mutation; however, the relative impact of "survival of the fittest" and "arrival of the fittest" on phenotypic...
4.
Conceicao I, Long A, Gruber J, Beldade P
PLoS One
. 2011 Sep;
6(8):e23778.
PMID: 21909358
Background: Analysis of genomic sequence allows characterization of genome content and organization, and access beyond gene-coding regions for identification of functional elements. BAC libraries, where relatively large genomic regions are...
5.
Gruber J
Methods Mol Biol
. 2011 Jan;
700:153-70.
PMID: 21204033
Genome-wide association studies are providing exciting new insight into the genetics of complex disease, but oftentimes, the genomic regions associated with the trait of interest are large enough to contain...
6.
Fontanillas P, Landry C, Wittkopp P, Russ C, Gruber J, Nusbaum C, et al.
Mol Ecol
. 2010 Mar;
19 Suppl 1:212-27.
PMID: 20331781
Differences in gene expression are thought to be an important source of phenotypic diversity, so dissecting the genetic components of natural variation in gene expression is important for understanding the...
7.
Gruber J, Long A
Genetics
. 2008 Dec;
181(2):661-70.
PMID: 19064705
Gene expression levels vary heritably, with approximately 25-35% of the loci affecting expression acting in cis. We characterized standing cis-regulatory variation among 16 wild-derived strains of Drosophila melanogaster. Our experiment's...
8.
Gruber J, Genissel A, Macdonald S, Long A
Genetics
. 2007 Feb;
175(4):1987-97.
PMID: 17277365
Currently, the relevance of common genetic variants--particularly those significantly associated with phenotypic variation in laboratory studies--to standing phenotypic variation in the wild is poorly understood. To address this, we quantified...
9.
Beldade P, Rudd S, Gruber J, Long A
BMC Genomics
. 2006 Jun;
7:130.
PMID: 16737530
Background: Butterfly wing color patterns are a key model for integrating evolutionary developmental biology and the study of adaptive morphological evolution. Yet, despite the biological, economical and educational value of...
10.
Vozarova de Courten B, Hanson R, Funahashi T, Lindsay R, Matsuzawa Y, Tanaka S, et al.
Diabetes
. 2004 Dec;
54(1):284-9.
PMID: 15616040
Adiponectin is an abundant adipose tissue-derived protein with important metabolic effects. Plasma adiponectin levels are decreased in obese individuals, and low adiponectin levels predict insulin resistance and type 2 diabetes....