Brian P H Metzger
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Explore the profile of Brian P H Metzger including associated specialties, affiliations and a list of published articles.
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15
Citations
369
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Recent Articles
1.
Park Y, Metzger B, Thornton J
bioRxiv
. 2024 Dec;
PMID: 39677708
We recently reanalyzed 20 combinatorial mutagenesis datasets using a novel reference-free analysis (RFA) method and showed that high-order epistasis contributes negligibly to protein sequence-function relationships in every case. Dupic, Phillips,...
2.
Sendker F, Schlotthauer T, Mais C, Lo Y, Girbig M, Bohn S, et al.
Nat Commun
. 2024 Dec;
15(1):10515.
PMID: 39627196
Many enzymes assemble into homomeric protein complexes comprising multiple copies of one protein. Because structural form is usually assumed to follow function in biochemistry, these assemblies are thought to evolve...
3.
Park Y, Metzger B, Thornton J
Nat Commun
. 2024 Sep;
15(1):7953.
PMID: 39261454
How complex are the rules by which a protein's sequence determines its function? High-order epistatic interactions among residues are thought to be pervasive, suggesting an idiosyncratic and unpredictable sequence-function relationship....
4.
Metzger B, Park Y, Starr T, Thornton J
Elife
. 2024 May;
12.
PMID: 38767330
A protein's genetic architecture - the set of causal rules by which its sequence produces its functions - also determines its possible evolutionary trajectories. Prior research has proposed that the...
5.
Metzger B
PLoS Biol
. 2024 May;
22(5):e3002627.
PMID: 38758732
The relationship between genetic code robustness and protein evolvability is unknown. A new study in PLOS Biology using in silico rewiring of genetic codes and functional protein data identified a...
6.
Park Y, Metzger B, Thornton J
bioRxiv
. 2023 Sep;
PMID: 37732229
How complicated is the genetic architecture of proteins - the set of causal effects by which sequence determines function? High-order epistatic interactions among residues are thought to be pervasive, making...
7.
Park Y, Metzger B, Thornton J
Science
. 2022 May;
376(6595):823-830.
PMID: 35587978
Epistatic interactions can make the outcomes of evolution unpredictable, but no comprehensive data are available on the extent and temporal dynamics of changes in the effects of mutations as protein...
8.
Hochberg G, Liu Y, Marklund E, Metzger B, Laganowsky A, Thornton J
Nature
. 2020 Dec;
588(7838):503-508.
PMID: 33299178
Most proteins assemble into multisubunit complexes. The persistence of these complexes across evolutionary time is usually explained as the result of natural selection for functional properties that depend on multimerization,...
9.
Metzger B, Wittkopp P
Evol Lett
. 2019 Oct;
3(5):448-461.
PMID: 31636938
Heritable variation in gene expression is common within species. Much of this variation is due to genetic differences outside of the gene with altered expression and is -acting. This -regulatory...
10.
Duveau F, Yuan D, Metzger B, Hodgins-Davis A, Wittkopp P
Proc Natl Acad Sci U S A
. 2017 Dec;
114(52):E11218-E11227.
PMID: 29259117
Phenotypic plasticity is an evolvable property of biological systems that can arise from environment-specific regulation of gene expression. To better understand the evolutionary and molecular mechanisms that give rise to...