Patricia J Wittkopp
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Explore the profile of Patricia J Wittkopp including associated specialties, affiliations and a list of published articles.
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73
Citations
3752
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Recent Articles
1.
Tian S, Asano Y, Banerjee T, Komata S, Wee J, Lamb A, et al.
Science
. 2024 Dec;
386(6726):1135-1141.
PMID: 39636974
In Lepidoptera (butterflies and moths), the genomic region around the gene is a "hotspot" locus, repeatedly implicated in generating intraspecific melanic wing color polymorphisms across 100 million years of evolution....
2.
Bayala E, Sinha P, Wittkopp P
STAR Protoc
. 2024 Nov;
5(4):103456.
PMID: 39576730
Visualizing RNA expression in the Drosophila epidermis during pupal development is challenging because the tissue is fragile during early pupal stages and increasingly impermeable at later stages. Here, we present...
3.
Siddiq M, Duveau F, Wittkopp P
Nat Ecol Evol
. 2024 Nov;
8(12):2184-2194.
PMID: 39537896
The environment influences how an organism's genotype determines its phenotype and how this phenotype affects its fitness. Here, to better understand this dual role of environment in the production and...
4.
Siddiq M, Duveau F, Wittkopp P
bioRxiv
. 2024 Apr;
PMID: 38659876
Phenotypic evolution is shaped by interactions between organisms and their environments. The environment influences how an organism's genotype determines its phenotype and how this phenotype affects its fitness. To better...
5.
Tian S, Asano Y, Banerjee T, Wee J, Lamb A, Wang Y, et al.
bioRxiv
. 2024 Apr;
PMID: 38659873
In Lepidoptera (butterflies and moths), the genomic region around the gene is a 'hotspot' locus, repeatedly used to generate intraspecific melanic wing color polymorphisms across 100-million-years of evolution. However, the...
6.
Ertl H, Bayala E, Siddiq M, Wittkopp P
bioRxiv
. 2024 Apr;
PMID: 38645200
Pioneer factors are critical for gene regulation and development because they bind chromatin and make DNA more accessible for binding by other transcription factors. The pioneer factor Grainy head (Grh)...
7.
Vande Zande P, Siddiq M, Hodgins-Davis A, Kim L, Wittkopp P
PLoS Genet
. 2023 Dec;
19(12):e1011078.
PMID: 38091349
Genetic networks are surprisingly robust to perturbations caused by new mutations. This robustness is conferred in part by compensation for loss of a gene's activity by genes with overlapping functions,...
8.
Nora E, Aerts S, Wittkopp P, Bussemaker H, Bulyk M, Sinha S, et al.
Cell Syst
. 2023 Apr;
14(4):247-251.
PMID: 37080160
What new questions can we ask about transcriptional regulation given recent developments in large-scale approaches?
9.
Lamb A, Wang Z, Simmer P, Chung H, Wittkopp P
Front Ecol Evol
. 2023 Apr;
8.
PMID: 37035752
pigmentation has been a fruitful model system for understanding the genetic and developmental mechanisms underlying phenotypic evolution. For example, prior work has shown that divergence of the gene contributes to...
10.
Wittkopp P
Philos Trans R Soc Lond B Biol Sci
. 2023 Apr;
378(1877):20220057.
PMID: 37004723
Heritable variation in gene expression is common within and among species and contributes to phenotypic diversity. Mutations affecting either - or -regulatory sequences controlling gene expression give rise to variation...