Jon M Lindstrom
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Explore the profile of Jon M Lindstrom including associated specialties, affiliations and a list of published articles.
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37
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1334
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Recent Articles
1.
Braunscheidel K, Voren G, Fowler C, Lu Q, Kuryatov A, Cameron M, et al.
Front Mol Neurosci
. 2024 Sep;
17:1459098.
PMID: 39346680
Background: Most smokers attempting to quit will quickly relapse to tobacco use even when treated with the most efficacious smoking cessation agents currently available. This highlights the need to develop...
2.
Xing H, Andrud K, Soti F, Rouchaud A, Jahn S, Lu Z, et al.
Mol Pharmacol
. 2020 Jun;
98(2):168-180.
PMID: 32474444
The two major nicotinic acetylcholine receptors (nAChRs) in the brain are the 42 and 7 subtypes. A "methyl scan" of the pyrrolidinium ring was used to detect differences in nicotine's...
3.
Papke R, Lindstrom J
Neuropharmacology
. 2020 Mar;
168:108021.
PMID: 32146229
Postsynaptic nAChRs in the peripheral nervous system are critical for neuromuscular and autonomic neurotransmission. Pre- and peri-synaptic nAChRs in the brain modulate neurotransmission and are responsible for the addictive effects...
4.
Ludwig R, Vanhoorelbeke K, Leypoldt F, Kaya Z, Bieber K, McLachlan S, et al.
Front Immunol
. 2017 Jun;
8:603.
PMID: 28620373
Autoantibodies are frequently observed in healthy individuals. In a minority of these individuals, they lead to manifestation of autoimmune diseases, such as rheumatoid arthritis or Graves' disease. Overall, more than...
5.
George A, Bloy A, Miwa J, Lindstrom J, Lukas R, Whiteaker P
FASEB J
. 2017 Jan;
31(4):1398-1420.
PMID: 28100642
This study investigates-for the first time to our knowledge-the existence and mechanisms of functional interactions between the endogenous mammalian prototoxin, lynx1, and α3- and β4-subunit-containing human nicotinic acetylcholine receptors (α3β4*-nAChRs)....
6.
McClure-Begley T, Esterlis I, Stone K, Lam T, Grady S, Colangelo C, et al.
eNeuro
. 2016 Aug;
3(4).
PMID: 27559543
Nicotinic acetylcholine receptors (nAChRs) support the initiation and maintenance of smoking, but the long-term changes occurring in the protein complex as a result of smoking and the nicotine in tobacco...
7.
Lucero L, Weltzin M, Eaton J, Cooper J, Lindstrom J, Lukas R, et al.
J Biol Chem
. 2015 Dec;
291(5):2444-59.
PMID: 26644472
Two α4β2 nicotinic acetylcholine receptor (α4β2-nAChR) isoforms exist with (α4)2(β2)3 and (α4)3(β2)2 subunit stoichiometries and high versus low agonist sensitivities (HS and LS), respectively. Both isoforms contain a pair of...
8.
Weltzin M, Lindstrom J, Lukas R, Whiteaker P
Neuropharmacology
. 2015 Nov;
102:158-73.
PMID: 26561946
Previously characterized nicotinic acetylcholine receptor (nAChR) autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE)-associated mutations are found in α2, α4 and β2 subunit transmembrane (TM) domains. They predominantly increase ACh potency...
9.
Shi M, Yue Z, Kuryatov A, Lindstrom J, Sehgal A
Elife
. 2014 Feb;
3:e01473.
PMID: 24497543
In this study, we report a new protein involved in the homeostatic regulation of sleep in Drosophila. We conducted a forward genetic screen of chemically mutagenized flies to identify short-sleeping...
10.
Jin Z, Khan P, Shin Y, Wang J, Lin L, Cameron M, et al.
Bioorg Med Chem Lett
. 2013 Dec;
24(2):674-8.
PMID: 24365158
The design and synthesis of a series of substituted heteroaromatic α4β2α5 positive allosteric modulators is reported. The optimization and development of the heteroaromatic series was carried out from NS9283, and...