J Michael McIntosh
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Explore the profile of J Michael McIntosh including associated specialties, affiliations and a list of published articles.
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253
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7736
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Recent Articles
1.
Tekarli B, Azam L, Hone A, McIntosh J
J Biol Chem
. 2025 Jan;
301(2):108182.
PMID: 39798871
Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels. In mammals, there are 16 individual nAChR subunits allowing for numerous possible heteromeric compositions. nAChRs assembled from α7 or α9 subunits...
2.
Azam L, Christensen S, Riaz Z, Kendell A, Cull J, Hone A, et al.
ACS Pharmacol Transl Sci
. 2024 Dec;
7(12):3935-3944.
PMID: 39698293
Nicotinic acetylcholine receptors containing the α9 subunit have been mechanistically implicated in alleviating chemotherapy-induced neuropathic pain. However, the cell types that underlie these effects are currently unknown. RgIA-5474 is a...
3.
Pei S, Wang N, Mei Z, Zhangsun D, Craik D, McIntosh J, et al.
Pharmacol Rev
. 2024 Jun;
76(5):828-845.
PMID: 38914468
Voltage-gated sodium (Na) channels are intimately involved in the generation and transmission of action potentials, and dysfunction of these channels may contribute to nervous system diseases, such as epilepsy, neuropathic...
4.
Hone A, Santiago U, Harvey P, Tekarli B, Gajewiak J, Craik D, et al.
J Med Chem
. 2024 May;
67(11):9587-9598.
PMID: 38814877
The spike-protein of SARS-CoV-2 has a distinctive amino-acid sequence (RRARS) that forms a cleavage site for the enzyme furin. Strikingly, the structure of the spike-protein loop containing the furin cleavage...
5.
Luo A, He J, Yu J, Wu Y, Harvey P, Kasheverov I, et al.
Int J Biol Macromol
. 2024 May;
271(Pt 1):132472.
PMID: 38772455
The two most active disulfide bond isomers of the analgesic αO-conotoxin GeXIVA, namely GeXIVA[1, 2] and GeXIVA[1, 4], were subjected to Asp-scanning mutagenesis to determine the key amino acid residues...
6.
Williams B, Steed N, Woolley J, Moedl A, Nelson C, Jones G, et al.
ACS Chem Neurosci
. 2024 Apr;
15(9):1738-1754.
PMID: 38613458
Iboga alkaloids, also known as coronaridine congeners, have shown promise in the treatment of alcohol and opioid use disorders. The objective of this study was to evaluate the effects of...
7.
Neves J, Urcino C, Chase K, Dowell C, Hone A, Morgenstern D, et al.
Mar Drugs
. 2024 Mar;
22(3).
PMID: 38535458
The venom of cone snails has been proven to be a rich source of bioactive peptides that target a variety of ion channels and receptors. α-Conotoxins (αCtx) interact with nicotinic...
8.
Wang H, Li X, Qiao Y, Wang M, Wang W, McIntosh J, et al.
Mar Drugs
. 2024 Jan;
22(1).
PMID: 38276651
Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting painful neuropathy that occurs commonly during cancer management, which often leads to the discontinuation of medication. Previous studies suggest that the α9α10 nicotinic...
9.
George A, John S, Lucero L, Eaton J, Jaiswal E, Christensen S, et al.
FASEB J
. 2024 Jan;
38(1):e23374.
PMID: 38161283
This study was undertaken to identify and characterize the first ligands capable of selectively identifying nicotinic acetylcholine receptors containing α7 and β2 subunits (α7β2-nAChR subtype). Basal forebrain cholinergic neurons express...
10.
Wu X, Hone A, Huang Y, Clark R, McIntosh J, Kaas Q, et al.
Chemistry
. 2023 Nov;
30(7):e202302909.
PMID: 37910861
Nicotinic acetylcholine receptors (nAChRs) are drug targets for neurological diseases and disorders, but selective targeting of the large number of nAChR subtypes is challenging. Marine cone snail α-conotoxins are potent...