Paul Whiteaker
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Explore the profile of Paul Whiteaker including associated specialties, affiliations and a list of published articles.
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76
Citations
2593
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Recent Articles
1.
Akinola L, Akinola L, Buzzi B, Kalck E, Le K, Klein S, et al.
Neuropharmacology
. 2025 Jan;
268:110315.
PMID: 39832529
Nicotine use remains one of the leading causes of preventable deaths in the United States and, while the prevalence of combustible cigarette use has declined over the past few years,...
2.
George A, John S, Lucero L, Eaton J, Jaiswal E, Christensen S, et al.
FASEB J
. 2024 Jan;
38(1):e23374.
PMID: 38161283
This study was undertaken to identify and characterize the first ligands capable of selectively identifying nicotinic acetylcholine receptors containing α7 and β2 subunits (α7β2-nAChR subtype). Basal forebrain cholinergic neurons express...
3.
Whiteaker P, George A
Pharmacol Res
. 2023 Apr;
191:106743.
PMID: 37084859
Initiated by findings that Alzheimer's disease is associated with a profound loss of cholinergic markers in human brain, decades of studies have examined the interactions between specific subtypes of nicotinic...
4.
Bavo F, Pallavicini M, Pucci S, Appiani R, Giraudo A, Oh H, et al.
J Med Chem
. 2022 Dec;
66(1):306-332.
PMID: 36526469
Modifications of the cationic head and the ethylene linker of 2-(triethylammonium)ethyl ether of 4-stilbenol (MG624) have been proved to produce selective α9*-nAChR antagonism devoid of any effect on the α7-subtype....
5.
Bavo F, Pallavicini M, Pucci S, Appiani R, Giraudo A, Eaton B, et al.
J Med Chem
. 2022 Jul;
65(14):10079-10097.
PMID: 35834819
Nicotinic acetylcholine receptors containing α9 subunits (α9*-nAChRs) are potential druggable targets arousing great interest for pain treatment alternative to opioids. Nonpeptidic small molecules selectively acting as α9*-nAChRs antagonists still remain...
6.
Kassner M, Eaton J, Tang N, Petit J, Meurice N, Yin H, et al.
SLAS Discov
. 2022 Jan;
27(1):68-76.
PMID: 35058178
There is substantial evidence that in addition to nicotine, other compounds found in tobacco smoke significantly influence smoking behavior. Further, recent years have seen an explosion in the availability of...
7.
Pisapati A, Cao W, Anderson K, Jones G, Holick K, Whiteaker P, et al.
FASEB Bioadv
. 2021 Dec;
3(12):1034-1042.
PMID: 34938964
Nicotinic acetylcholine receptors (nAChRs) are broadly expressed in the central and peripheral nervous systems, playing essential roles in cholinergic neurotransmission. The lynx family proteins, a subset of the Ly6/uPAR superfamily...
8.
Weltzin M, George A, Lukas R, Whiteaker P
PLoS One
. 2021 Mar;
16(3):e0247825.
PMID: 33657187
Sleep-related hypermotor epilepsy (SHE) is a group of seizure disorders prominently associated with mutations in nicotinic acetylcholine receptors (nAChR). The most prevalent central nervous system nAChR subtype contains α4 and...
9.
George A, Vieira J, Xavier-Jackson C, Gee M, Cirrito J, Bimonte-Nelson H, et al.
J Neurosci
. 2020 Nov;
41(3):555-575.
PMID: 33239400
Neuronal and network-level hyperexcitability is commonly associated with increased levels of amyloid-β (Aβ) and contribute to cognitive deficits associated with Alzheimer's disease (AD). However, the mechanistic complexity underlying the selective...
10.
Liu Q, Li M, Whiteaker P, Shi F, Morley B, Lukas R
Biomolecules
. 2019 Dec;
9(12).
PMID: 31817275
Experimental autoimmune encephalomyelitis (EAE) is attenuated in nicotinic acetylcholine receptor (nAChR) α9 subunit knock-out (α9 KO) mice. However, protection is incomplete, raising questions about roles for related, nAChR α10 subunits...