Jon Frampton
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Explore the profile of Jon Frampton including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Clarke M, Gabrielsen O, Frampton J
Adv Exp Med Biol
. 2024 Jul;
1459:341-358.
PMID: 39017851
Myb was identified over four decades ago as the transforming component of acute leukemia viruses in chickens. Since then it has become increasingly apparent that dysregulated MYB activity characterizes many...
2.
Lemma R, Fuglerud B, Frampton J, Gabrielsen O
Adv Exp Med Biol
. 2024 Jul;
1459:3-29.
PMID: 39017837
MYB is a master regulator and pioneer factor highly expressed in hematopoietic progenitor cells (HPCs) where it contributes to the reprogramming processes operating during hematopoietic development. MYB plays a complex...
3.
Cui Y, Lanne A, Peng X, Browne E, Bhatt A, Coltman N, et al.
J Med Chem
. 2024 Feb;
67(4):2529-2548.
PMID: 38331432
Tuberculosis (TB) is the leading cause of global morbidity and mortality resulting from infectious disease, with over 10.6 million new cases and 1.4 million deaths in 2021. This global emergency...
4.
Clarke M, Lemma R, Walton D, Volpe G, Noyvert B, Gabrielsen O, et al.
Blood
. 2023 Jan;
141(15):1858-1870.
PMID: 36603185
MYB plays a key role in gene regulation throughout the hematopoietic hierarchy and is critical for the maintenance of normal hematopoietic stem cells (HSC). Acquired genetic dysregulation of MYB is...
5.
Owen A, Patten D, Vigneswara V, Frampton J, Newsome P
Stem Cells
. 2022 Aug;
40(11):1056-1070.
PMID: 35999023
Liver transplantation is an effective therapy, but increasing demand for donor organs has led to the use of marginal donor organs with increased complication rates. Mesenchymal stromal cells (MSC) pleiotropically...
6.
Babarinde I, Ma G, Li Y, Deng B, Luo Z, Liu H, et al.
Nucleic Acids Res
. 2021 Aug;
49(16):9132-9153.
PMID: 34390351
Transposable elements (TEs) occupy nearly 40% of mammalian genomes and, whilst most are fragmentary and no longer capable of transposition, they can nevertheless contribute to cell function. TEs within genes...
7.
Volpe G, Cauchy P, Walton D, Ward C, Blakemore D, Bayley R, et al.
Life Sci Alliance
. 2019 Mar;
2(2).
PMID: 30877232
Mutations at the N- or C-terminus of C/EBPα are frequent in acute myeloid leukaemia (AML) with normal karyotype. Here, we investigate the role of the transcription factor Myb in AMLs...
8.
Schmidt L, Heyes E, Scheiblecker L, Eder T, Volpe G, Frampton J, et al.
Leukemia
. 2019 Jan;
33(7):1608-1619.
PMID: 30679799
The gene encoding the transcription factor C/EBPα is mutated in 10-15% of acute myeloid leukemia (AML) patients. N-terminal CEBPA mutations cause ablation of full-length C/EBPα without affecting the expression of...
9.
Ward C, Volpe G, Cauchy P, Ptasinska A, Almaghrabi R, Blakemore D, et al.
Cell Rep
. 2018 Aug;
24(6):1496-1511.e8.
PMID: 30089261
During somatic reprogramming, Yamanaka's pioneer factors regulate a complex sequence of molecular events leading to the activation of a network of pluripotency factors, ultimately resulting in the acquisition and maintenance...
10.
Sheriff L, Alanazi A, Ward L, Ward C, Munir H, Rayes J, et al.
Stem Cells
. 2018 Mar;
36(7):1062-1074.
PMID: 29488279
We investigated the adhesive behavior of mesenchymal stem cells (MSC) in blood, which might influence their fate when infused as therapy. Isolated human bone marrow MSC (BMMSC) or umbilical cord...