John W Hickey
Overview
Explore the profile of John W Hickey including associated specialties, affiliations and a list of published articles.
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43
Citations
1072
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Recent Articles
21.
Igarashi K, Kucinski I, Chan Y, Tan T, Khoo H, Kealy D, et al.
Blood Adv
. 2023 Feb;
7(14):3366-3377.
PMID: 36809781
Hematopoietic stem cells (HSCs) are a rare type of hematopoietic cell that can entirely reconstitute the blood and immune system after transplantation. Allogeneic HSC transplantation (HSCT) is used clinically as...
22.
Chen S, Zhu B, Huang S, Hickey J, Lin K, Snyder M, et al.
bioRxiv
. 2023 Jan;
PMID: 36711792
single-cell sequencing methods have enabled the profiling of multiple types of molecular readouts at cellular resolution, and recent developments in spatial barcoding, in situ hybridization, and in situ sequencing allow...
23.
Matusiak M, Hickey J, Luca B, Lu G, Kidzinski L, Zhu S, et al.
Res Sq
. 2023 Jan;
PMID: 36711732
Tumor-associated macrophages (TAMs) display heterogeneous phenotypes. Yet the exact tissue cues that shape macrophage functional diversity are incompletely understood. Here we discriminate, spatially resolve and reveal the function of five...
24.
Brbic M, Cao K, Hickey J, Tan Y, Snyder M, Nolan G, et al.
Nat Methods
. 2022 Oct;
19(11):1411-1418.
PMID: 36280720
Accurate cell-type annotation from spatially resolved single cells is crucial to understand functional spatial biology that is the basis of tissue organization. However, current computational methods for annotating spatially resolved...
25.
Lu G, Baertsch M, Hickey J, Goltsev Y, Rech A, Mani L, et al.
Front Immunol
. 2022 Oct;
13:981825.
PMID: 36211386
Highly multiplexed, single-cell imaging has revolutionized our understanding of spatial cellular interactions associated with health and disease. With ever-increasing numbers of antigens, region sizes, and sample sizes, multiplexed fluorescence imaging...
26.
Jiang S, Mukherjee N, Bennett R, Chen H, Logue J, Dighero-Kemp B, et al.
Front Immunol
. 2021 Dec;
12:729845.
PMID: 34938283
Non-human primate (NHP) animal models are an integral part of the drug research and development process. For some biothreat pathogens, animal model challenge studies may offer the only possibility to...
27.
Baertsch M, Nolan G, Hickey J
Trends Cancer
. 2021 Dec;
8(3):164-173.
PMID: 34872889
The complex determinants of health and disease can be determined when approached as a system of interactions of biological agents at different scales. Similar to the physicochemical properties that govern...
28.
Hickey J, Neumann E, Radtke A, Camarillo J, Beuschel R, Albanese A, et al.
Nat Methods
. 2021 Nov;
19(3):284-295.
PMID: 34811556
Tissues and organs are composed of distinct cell types that must operate in concert to perform physiological functions. Efforts to create high-dimensional biomarker catalogs of these cells have been largely...
29.
Hickey J, Tan Y, Nolan G, Goltsev Y
Front Immunol
. 2021 Sep;
12:727626.
PMID: 34484237
Multiplexed imaging is a recently developed and powerful single-cell biology research tool. However, it presents new sources of technical noise that are distinct from other types of single-cell data, necessitating...
30.
Black S, Phillips D, Hickey J, Kennedy-Darling J, Venkataraaman V, Samusik N, et al.
Nat Protoc
. 2021 Jul;
16(8):3802-3835.
PMID: 34215862
Advances in multiplexed imaging technologies have drastically improved our ability to characterize healthy and diseased tissues at the single-cell level. Co-detection by indexing (CODEX) relies on DNA-conjugated antibodies and the...