Jeffrey M Spraggins
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Explore the profile of Jeffrey M Spraggins including associated specialties, affiliations and a list of published articles.
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100
Citations
1962
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Recent Articles
1.
Zhang Y, Huang L, Pillar N, Li Y, Migas L, Van de Plas R, et al.
ArXiv
. 2024 Nov;
PMID: 39606731
Imaging mass spectrometry (IMS) is a powerful tool for untargeted, highly multiplexed molecular mapping of tissue in biomedical research. IMS offers a means of mapping the spatial distributions of molecular...
2.
Esselman A, Moser F, Tideman L, Migas L, Djambazova K, Colley M, et al.
Kidney Int
. 2024 Nov;
107(2):332-337.
PMID: 39571907
Glomeruli filter blood through the coordination of podocytes, mesangial cells, fenestrated endothelial cells, and the glomerular basement membrane. Cellular changes, such as podocyte loss, are associated with pathologies like diabetic...
3.
Lee H, Saunders A, Kim M, Remedios S, Remedios L, Tang Y, et al.
J Med Imaging (Bellingham)
. 2024 Nov;
11(6):064004.
PMID: 39554509
Purpose: Eye morphology varies significantly across the population, especially for the orbit and optic nerve. These variations limit the feasibility and robustness of generalizing population-wise features of eye organs to...
4.
Esselman A, Ward M, Marshall C, Pingry E, Dufresne M, Farrow M, et al.
J Am Soc Mass Spectrom
. 2024 Nov;
35(12):2795-2800.
PMID: 39510845
Matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) is a rapidly advancing technology for biomedical research. As spatial resolution increases, however, so do acquisition time, file size, and experimental cost,...
5.
Kaur H, Heiser C, McKinley E, Ventura-Antunes L, Harris C, Roland J, et al.
Commun Biol
. 2024 Oct;
7(1):1295.
PMID: 39478141
Spatially resolved molecular assays provide high dimensional genetic, transcriptomic, proteomic, and epigenetic information in situ and at various resolutions. Pairing these data across modalities with histological features enables powerful studies...
6.
Kruse A, Judd A, Gutierrez D, Allen J, Dufresne M, Farrow M, et al.
Anal Chem
. 2024 Oct;
96(42):16861-16870.
PMID: 39392310
Thermal denaturation (TD), known as antigen retrieval, heats tissue samples in a buffered solution to expose protein epitopes. Thermal denaturation of formalin-fixed paraffin-embedded samples enhances on-tissue tryptic digestion, increasing peptide...
7.
Good C, Butrico C, Colley M, Emmerson L, Gibson-Corley K, Cassat J, et al.
Cell Chem Biol
. 2024 Oct;
31(10):1852-1868.e5.
PMID: 39389064
Osteomyelitis occurs when Staphylococcus aureus invades the bone microenvironment, resulting in a bone marrow abscess with a spatially defined architecture of cells and biomolecules. Imaging mass spectrometry and microscopy are...
8.
Djambazova K, Gibson-Corley K, Freiberg J, Caprioli R, Skaar E, Spraggins J
J Am Soc Mass Spectrom
. 2024 Jul;
35(8):1692-1701.
PMID: 39052897
Gangliosides play important roles in innate and adaptive immunity. The high degree of structural heterogeneity results in significant variability in ganglioside expression patterns and greatly complicates linking structure and function....
9.
Brewer M, Migas L, Clouthier K, Allen J, Anderson D, Pingry E, et al.
Am J Physiol Renal Physiol
. 2024 May;
327(1):F91-F102.
PMID: 38721662
The lack of standardization in antibody validation remains a major contributor to irreproducibility of human research. To address this, we have applied a standardized approach to validate a panel of...
10.
Colley M, Esselman A, Scott C, Spraggins J
Annu Rev Anal Chem (Palo Alto Calif)
. 2024 Apr;
17(1):1-24.
PMID: 38594938
Imaging mass spectrometry (IMS) enables highly multiplexed, untargeted tissue mapping for a broad range of molecular classes, facilitating in situ biological discovery. Yet, challenges persist in molecular specificity, which is...