John W Hickey
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Explore the profile of John W Hickey including associated specialties, affiliations and a list of published articles.
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43
Citations
1072
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Recent Articles
11.
Bialy N, Alber F, Andrews B, Angelo M, Beliveau B, Bintu L, et al.
ArXiv
. 2024 Feb;
PMID: 38351940
Together with the molecular knowledge of genes and proteins, biological images promise to significantly enhance the scientific understanding of complex cellular systems and to advance predictive and personalized therapeutic products...
12.
Hickey J, Agmon E, Horowitz N, Lamore M, Sunwoo J, Covert M, et al.
bioRxiv
. 2023 Dec;
PMID: 38106218
Cancer progression is a complex process involving interactions that unfold across molecular, cellular, and tissue scales. These multiscale interactions have been difficult to measure and to simulate. Here we integrated...
13.
Hickey J, Haist M, Horowitz N, Caraccio C, Tan Y, Rech A, et al.
Cell Rep
. 2023 Dec;
42(12):113494.
PMID: 38085642
Antigen-specific T cells traffic to, are influenced by, and create unique cellular microenvironments. Here we characterize these microenvironments over time with multiplexed imaging in a melanoma model of adoptive T ...
14.
Chen S, Zhu B, Huang S, Hickey J, Lin K, Snyder M, et al.
Nat Biotechnol
. 2023 Sep;
42(7):1096-1106.
PMID: 37679544
Although single-cell and spatial sequencing methods enable simultaneous measurement of more than one biological modality, no technology can capture all modalities within the same cell. For current data integration methods,...
15.
Jain S, Pei L, Spraggins J, Angelo M, Carson J, Gehlenborg N, et al.
Nat Cell Biol
. 2023 Jul;
25(8):1089-1100.
PMID: 37468756
The Human BioMolecular Atlas Program (HuBMAP) aims to create a multi-scale spatial atlas of the healthy human body at single-cell resolution by applying advanced technologies and disseminating resources to the...
16.
Quardokus E, Saunders D, McDonough E, Hickey J, Werlein C, Surrette C, et al.
Nat Methods
. 2023 Jul;
20(8):1174-1178.
PMID: 37468619
Multiplexed antibody-based imaging enables the detailed characterization of molecular and cellular organization in tissues. Advances in the field now allow high-parameter data collection (>60 targets); however, considerable expertise and capital...
17.
Hickey J, Becker W, Nevins S, Horning A, Perez A, Zhu C, et al.
Nature
. 2023 Jul;
619(7970):572-584.
PMID: 37468586
The intestine is a complex organ that promotes digestion, extracts nutrients, participates in immune surveillance, maintains critical symbiotic relationships with microbiota and affects overall health. The intesting has a length...
18.
Jain Y, Godwin L, Ju Y, Sood N, Quardokus E, Bueckle A, et al.
Commun Biol
. 2023 Jul;
6(1):717.
PMID: 37468557
The Human BioMolecular Atlas Program (HuBMAP) aims to compile a Human Reference Atlas (HRA) for the healthy adult body at the cellular level. Functional tissue units (FTUs), relevant for HRA...
19.
Strasser M, Gibbs D, Gascard P, Bons J, Hickey J, Schurch C, et al.
bioRxiv
. 2023 Jun;
PMID: 37333362
Esophageal adenocarcinoma arises from Barrett's esophagus, a precancerous metaplastic replacement of squamous by columnar epithelium in response to chronic inflammation. Multi-omics profiling, integrating single-cell transcriptomics, extracellular matrix proteomics, tissue-mechanics and...
20.
Ben-Akiva E, Hickey J, Meyer R, Isser A, Shannon S, Livingston N, et al.
Acta Biomater
. 2023 Feb;
160:187-197.
PMID: 36812956
Artificial antigen presenting cells are biomimetic particles that recapitulate the signals presented by natural antigen presenting cells in order to stimulate T cells in an antigen-specific manner using an acellular...