John Thyfault
Overview
Explore the profile of John Thyfault including associated specialties, affiliations and a list of published articles.
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14
Citations
150
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Recent Articles
1.
Alissa N, Fang W, Medrano M, Bergeron N, Kozai Y, Hu Q, et al.
Dis Model Mech
. 2024 Jul;
17(8).
PMID: 38973385
Despite advancements in treatment, approximately 25% of patients with breast cancer experience long-term skeletal muscle wasting (SMW), which limits mobility, reduces drug tolerance and adversely impacts survival. By understanding the...
2.
Amar D, Gay N, Jimenez-Morales D, Jean Beltran P, Ramaker M, Raja A, et al.
Cell Metab
. 2024 May;
36(6):1411-1429.e10.
PMID: 38701776
Mitochondria have diverse functions critical to whole-body metabolic homeostasis. Endurance training alters mitochondrial activity, but systematic characterization of these adaptations is lacking. Here, the Molecular Transducers of Physical Activity Consortium...
3.
Paine-Cabrera D, Harvey L, Robarts D, Pritchard M, Thyfault J, Weinman S, et al.
Clin Transl Sci
. 2023 Oct;
16(12):2719-2728.
PMID: 37877453
Non-alcoholic fatty liver disease (NAFLD), newly renamed metabolic dysfunction-associated liver disease (MASLD), is a leading cause of liver disease in children and adults. There is a paucity of data surrounding...
4.
Ma X, Manley S, Qian H, Li Y, Zhang C, Li K, et al.
Cell Rep
. 2023 Oct;
42(10):113291.
PMID: 37862166
Dysfunctional mitochondria are removed via multiple pathways, such as mitophagy, a selective autophagy process. Here, we identify an intracellular hybrid mitochondria-lysosome organelle (termed the mitochondria-lysosome-related organelle [MLRO]), which regulates mitochondrial...
5.
Carlson J, Hibbing P, Forseth B, Diaz K, Sotres-Alvarez D, Bejarano C, et al.
J Am Heart Assoc
. 2023 Sep;
12(18):e028495.
PMID: 37681558
Background There is limited evidence on the potential negative metabolic health impacts of prolonged and uninterrupted sedentary bouts in structurally disadvantaged youth. This study investigated associations between sedentary bout variables...
6.
Amar D, Gay N, Jimenez-Morales D, Jean Beltran P, Ramaker M, Raja A, et al.
bioRxiv
. 2023 Jan;
PMID: 36711881
Mitochondria are adaptable organelles with diverse cellular functions critical to whole-body metabolic homeostasis. While chronic endurance exercise training is known to alter mitochondrial activity, these adaptations have not yet been...
7.
Jiang X, Fulte S, Deng F, Chen S, Xie Y, Chao X, et al.
J Hepatol
. 2022 Apr;
77(3):619-631.
PMID: 35452693
Background & Aims: Vacuole membrane protein 1 (VMP1) is an endoplasmic reticulum (ER) transmembrane protein that regulates the formation of autophagosomes and lipid droplets. Recent evidence suggests that VMP1 plays...
8.
Sedentary Behavior Counseling Intervention in Aging People With Type 2 Diabetes: A Feasibility Study
Alothman S, Alenazi A, Alshehri M, LeMaster J, Thyfault J, Rucker J, et al.
Clin Med Insights Endocrinol Diabetes
. 2021 Nov;
14:11795514211040540.
PMID: 34776731
This study examined the feasibility and effect of sedentary behavior (SB) counseling on total sitting time (TST) and glycemic control in people with type 2 diabetes (T2D). Community-dwelling sedentary adults...
9.
Huck I, Morris E, Thyfault J, Apte U
Gene Expr
. 2021 Mar;
20(3):157-168.
PMID: 33691903
Hepatocyte nuclear factor 4 alpha (HNF4) is required for hepatocyte differentiation and regulates expression of genes involved in lipid and carbohydrate metabolism including those that control VLDL secretion and gluconeogenesis....
10.
Mercer K, Maurer A, Pack L, Ono-Moore K, Spray B, Campbell C, et al.
Am J Physiol Endocrinol Metab
. 2021 Mar;
320(5):E864-E873.
PMID: 33645254
Regular exercise has profound metabolic influence on the liver, but effects on bile acid (BA) metabolism are less well known. BAs are synthesized exclusively in the liver from cholesterol via...