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John T Koh

Explore the profile of John T Koh including associated specialties, affiliations and a list of published articles. Areas
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Articles 24
Citations 182
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Recent Articles
1.
Zhang Y, Mantravadi P, Jobbagy S, Bao W, Koh J
ACS Chem Biol . 2016 Aug; 11(10):2797-2802. PMID: 27548116
The Androgen Receptor (AR) remains the leading target of advanced prostate cancer therapies. Thiosalicylamide analogs have previously been shown to act in cells as acyltransfer catalysts that are capable of...
2.
Ceo L, Koh J
Chembiochem . 2012 Jan; 13(4):511-3. PMID: 22271631
Spot lit: photocaged nucleic acids have been used to regulate gene expression through the action of light. Whereas most methods target mRNAs, DNA decoys have recently been used to target...
3.
Jain D, Koh J
Bioorg Med Chem Lett . 2010 Jul; 20(17):5258-61. PMID: 20659801
Estrogen receptors (ERs) regulate gene transcription through classic estrogen response elements (EREs) as well as AP-1 responsive genes. The common SERMs Raloxifene, Tamoxifen, and ICI164384 function as ER antagonists on...
4.
Sauers D, Temburni M, Biggins J, Ceo L, Galileo D, Koh J
ACS Chem Biol . 2010 Jan; 5(3):313-20. PMID: 20050613
Light-directed gene patterning methods have been described as a means to regulate gene expression in a spatially and temporally controlled manner. Several methods have been reported that use photocaged forms...
5.
Fotos J, Patel V, Karin N, Temburni M, Koh J, Galileo D
Cytotechnology . 2008 Nov; 51(1):7-19. PMID: 19002890
We describe a novel fully automated high-throughput time-lapse microscopy system and evaluate its performance for precisely tracking the motility of several glioma and osteoblastic cell lines. Use of this system...
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7.
Zheng J, Hashimoto A, Putnam M, Miller K, Koh J
Bioconjug Chem . 2008 May; 19(6):1227-34. PMID: 18507428
Molecular conjugates of hormone receptor-ligands with molecular probes or functional domains are finding diverse applications in chemical biology. Whereas many examples of hormone conjugates that target steroid hormone receptors have...
8.
Koh J, Zheng J
ACS Chem Biol . 2007 Sep; 2(9):599-601. PMID: 17894442
While many research programs have focused on the challenge of developing small molecules that can inhibit protein-protein interactions, some researchers have taken the problem one step further by attempting to...
9.
Biggins J, Hashimoto A, Koh J
Chembiochem . 2007 Mar; 8(7):799-803. PMID: 17393546
Nuclear hormone receptors (NHRs) represent a diverse class of ligand-dependent transcriptional regulators. NHRs that have been rendered functionally inactive due to mutations that abrogate proper ligand binding can often be...
10.
McGinley P, Koh J
J Am Chem Soc . 2007 Mar; 129(13):3822-3. PMID: 17348658
No abstract available.