John T Koh
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Explore the profile of John T Koh including associated specialties, affiliations and a list of published articles.
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24
Citations
182
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Recent Articles
11.
Posner G, Suh B, Petersen K, Dolan P, Agoston E, Kensler T, et al.
J Steroid Biochem Mol Biol
. 2007 Jan;
103(3-5):213-21.
PMID: 17218093
Three new Vitamin D analogs 3-5 incorporating a -CHF(2) group as an -OH surrogate have been prepared. Two of these new analogs (3 and 5) are strongly antiproliferative toward murine...
12.
Biggins J, Koh J
Curr Opin Chem Biol
. 2006 Dec;
11(1):99-110.
PMID: 17188557
The nuclear hormone receptors are ligand-gated transcription factors that modulate gene expression by directly acting upon genomic DNA, and have been of profound interest across all biological disciplines. Recent advancements...
13.
Hassan A, Koh J
J Am Chem Soc
. 2006 Jul;
128(27):8868-74.
PMID: 16819881
Nuclear receptors are ligand-dependent transcription factors that are of interest as potential tools to artificially regulate gene expression. Ligand binding induces a conformational change involving helix-12 which forms part of...
14.
Link K, Shi Y, Koh J
J Am Chem Soc
. 2005 Sep;
127(38):13088-9.
PMID: 16173704
Many genes elicit their actions through their expression in precise spatial patterns in tissues. Photoregulated expression systems offer a means to remotely pattern gene expression in tissues. Using currently available...
15.
Koh J, Biggins J
Curr Top Med Chem
. 2005 May;
5(4):413-20.
PMID: 15892683
In some instances, small molecules can restore function to proteins that are impaired by genetic mutations. There are now many examples where non-specific molecules or specific ligands can act as...
16.
Hashimoto A, Shi Y, Drake K, Koh J
Bioorg Med Chem
. 2005 May;
13(11):3627-39.
PMID: 15862991
The thyroid hormone receptors (TR) are ligand-dependant transcription factors that regulate key genes involved in metabolic regulation, thermogenesis and development. Resistance to thyroid hormone (RTH) is a genetic disease associated...
17.
Shi Y, Ye H, Link K, Putnam M, Hubner I, Dowdell S, et al.
Biochemistry
. 2005 Mar;
44(12):4612-26.
PMID: 15779888
The thyroid hormone receptors (TRs) are ligand-dependent transcription factors that control the expression of multiple genes involved in development and homeostasis in response to thyroid hormone (triiodothyronine, T3). Mutations to...
18.
Link K, Cruz F, Ye H, OReilly K, Dowdell S, Koh J
Bioorg Med Chem
. 2004 Oct;
12(22):5949-59.
PMID: 15498671
Light-activated gene expression systems hold promise as new tools for studying spatial and temporal gene patterning in multicellular systems. Photo-caged forms of nuclear receptor agonists have recently been shown to...
19.
Shi Y, Koh J
Chembiochem
. 2004 Jun;
5(6):788-96.
PMID: 15174161
Recently developed methods to regulate the spatial and temporal patterning of genes in a light-directed manner hold promise as powerful tools for exploring the function of genes that act through...
20.