John S Williamson
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Explore the profile of John S Williamson including associated specialties, affiliations and a list of published articles.
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17
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73
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Recent Articles
1.
Tantry M, Idris A, Williamson J, Shafi T, Dar J, Malik T, et al.
Heliyon
. 2019 Jan;
4(12):e01046.
PMID: 30603688
The differential solvent extraction and further purification of fractions of endophytic sp. isolated from led to the isolation of further two perylenequinone compounds as 3,6,6a,9,10-pentahydroxy-7,8-epoxy-4-oxo-4,5,6,6a,6b,7,8,9-octahydroperylene () and 3,6,6a,7,10-pentahydroxy-4,9-dioxo-4,5,6,6a,6b,7,8,9-octahydroperylene (). Structure...
2.
Zhan Y, Wu Y, Xu F, Bai Y, Guan Y, Williamson J, et al.
Fitoterapia
. 2017 Jun;
120:93-97.
PMID: 28576722
Microbial transformation of artemisinin (1) by Cunninghamella elegans was investigated. Four isolated products were identified as 6β-hydroxyartemisinin (2), 7α-hydroxyartemisinin (3), 7β-hydroxyartemisinin (4), and 6β,7α-dihydroxyartemisinin (5). The structures were elucidated by...
3.
Sorkin B, Kuszak A, Williamson J, Hopp D, Betz J
Adv Nutr
. 2016 Mar;
7(2):383-9.
PMID: 26980822
Inconsistent and contradictory results from nutrition studies conducted by different investigators continue to emerge, in part because of the inherent variability of natural products, as well as the unknown and...
4.
Zhan Y, Liu H, Wu Y, Wei P, Chen Z, Williamson J
Appl Microbiol Biotechnol
. 2015 Feb;
99(8):3443-6.
PMID: 25712678
Biotransformation of artemisinin (1) by Aspergillus niger was investigated. During 12 days at 28 °C and pH 6.0, A. niger transformed artemisinin into four products. They were identified as 3β-hydroxy-4,12-epoxy-1-deoxyartemisinin...
5.
Chatterjee A, Cutler S, Doerksen R, Khan I, Williamson J
Bioorg Med Chem
. 2014 Dec;
22(22):6409-21.
PMID: 25438765
Calpain mediated cleavage of CDK5 natural precursor p35 causes a stable complex formation of CDK5/p25, which leads to hyperphosphorylation of tau. Thus inhibition of this complex is a viable target...
6.
Chatterjee A, Cutler S, Khan I, Williamson J
Mol Divers
. 2013 Sep;
18(1):51-9.
PMID: 24026508
The first reported synthesis of potential kinase inhibitors, 4-oxo-4,5-dihydrothieno[3,2-c]quinoline-2-carboxylic acid derivatives starting from aniline is described. This efficient high yielding sequence was carried out in six steps without any chromatographic...
7.
Pabbisetty D, Illendula A, Muraleedharan K, Chittiboyina A, Williamson J, Avery M, et al.
J Chromatogr B Analyt Technol Biomed Life Sci
. 2012 Feb;
889-890:123-9.
PMID: 22365535
Among all the antimalarial agents, artemisinin and its semi synthetic family of analogs are the most potent antimalarials available for the treatment of Plasmodium falciparum infections. But these analogs have...
8.
Carvalho P, Liu B, Wu Y, Williamson J, Avery M
Acta Crystallogr Sect E Struct Rep Online
. 2011 Jan;
64(Pt 2):o395-6.
PMID: 21201424
CRYSTALS OF THE TITLE COMPOUND [SYSTEMATIC NAME: (3R,6R,7S,8aR,9R,12aR)-7-hydr-oxy-3,6,9-trimethyl-octa-hydro-3,12-ep-oxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one], C(15)H(22)O(6), were obtained from microbial transformation of artemisinin by a culture of Cunninghamella elegans. The stereochemistry of the compound is consistent with...
9.
Rodriguez-Guzman R, Radwan M, Burandt C, Williamson J, Ross S
Nat Prod Commun
. 2010 Oct;
5(9):1463-4.
PMID: 20923009
Phytochemical evaluation of Zanthoxylum monophyllum has led to the isolation of the alkaloid 4-methoxy-N-methyl-2-quinolone (1) with a significant activity against methicillin-resistant Staphylococcus aureus (MRSA), with an IC50 value of 1.5...
10.
Miller T, Friedman J, Williamson J, Schaffer L, Viggiano A
Rev Sci Instrum
. 2009 Apr;
80(3):034104.
PMID: 19334937
A new high temperature flowing afterglow Langmuir probe (HT-FALP) apparatus is described. A movable Langmuir probe and a four-needle reactant gas inlet were fitted to an existing high temperature flowing...