John R Teijaro
Overview
Explore the profile of John R Teijaro including associated specialties, affiliations and a list of published articles.
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90
Citations
5756
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Recent Articles
1.
Davis-Porada J, George A, Lam N, Caron D, Gray J, Huang J, et al.
Immunity
. 2024 Nov;
57(12):2895-2913.e8.
PMID: 39510068
Memory T and B cells in tissues are essential for protective immunity. Here, we performed a comprehensive analysis of the tissue distribution, phenotype, durability, and transcriptional profile of COVID-19 mRNA...
2.
Shaabani N, Zak J, Johnson J, Huang Z, Nguyen N, Lazar D, et al.
J Immunol
. 2024 Nov;
213(12):1811-1824.
PMID: 39495004
ISG15, an IFN-stimulated gene, plays a crucial role in modulating immune responses during viral infections. Its upregulation is part of the host's defense mechanism against viruses, contributing to the antiviral...
3.
Wang C, Hou Y, Zak J, Zheng Q, McCord K, Wu M, et al.
bioRxiv
. 2024 Oct;
PMID: 39416090
Cancer treatment has been rapidly transformed by the development of immune checkpoint inhibitors targeting CTLA-4 and PD-1/PD-L1. However, many patients fail to respond, especially those with an immunosuppressive tumor microenvironment...
4.
Sakai A, Singh G, Khoshbakht M, Bittner S, Lohr C, Diaz-Tapia R, et al.
Mol Ther Nucleic Acids
. 2024 Oct;
35(4):102331.
PMID: 39376996
Further development of direct-acting antiviral agents against human SARS-CoV-2 infections remains a public health priority. Here, we report that an antisense peptide-conjugated morpholino oligomer (PPMO) named 5'END-2, targeting a highly...
5.
Hou Y, Zak J, Shi Y, Pratumchai I, Dinner B, Wang W, et al.
Cancer Immunol Res
. 2024 Oct;
13(1):47-65.
PMID: 39365901
The histone methyltransferase enhancer of zeste homolog 2 (EZH2) plays important roles in T-cell differentiation, proliferation, and function. Previous studies have demonstrated that genetic deletion of EZH2 in CD8+ or...
6.
Nennig K, Murthy S, Maloney S, Shaw T, Sharobim M, Matkovic E, et al.
PLoS Pathog
. 2024 Aug;
20(8):e1012436.
PMID: 39196893
Viruses capable of causing persistent infection have developed sophisticated mechanisms for evading host immunity, and understanding these processes can reveal novel features of the host immune system. One such virus,...
7.
Shepard R, Ghebremedhin A, Pratumchai I, Robinson S, Betts C, Hu J, et al.
Sci Transl Med
. 2024 Jul;
16(754):eadi6887.
PMID: 38959328
Virulent infectious agents such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and methicillin-resistant (MRSA) induce tissue damage that recruits neutrophils, monocyte, and macrophages, leading to T cell exhaustion, fibrosis,...
8.
Zak J, Pratumchai I, Marro B, Marquardt K, Zavareh R, Lairson L, et al.
Science
. 2024 Jun;
384(6702):eade8520.
PMID: 38900864
Unleashing antitumor T cell activity by checkpoint inhibitor immunotherapy is effective in cancer patients, but clinical responses are limited. Cytokine signaling through the Janus kinase (JAK)-signal transducer and activator of...
9.
Yang Z, Hou Y, Grande G, Cho J, Wang C, Shi Y, et al.
Nat Biomed Eng
. 2024 May;
8(5):499-512.
PMID: 38693431
Bispecific T-cell engagers (BiTEs) bring together tumour cells and cytotoxic T cells by binding to specific cell-surface tumour antigens and T-cell receptors, and have been clinically successful for the treatment...
10.
Orozco R, Marquardt K, Pratumchai I, Shaikh A, Mowen K, Domissy A, et al.
PLoS Pathog
. 2024 Mar;
20(3):e1012095.
PMID: 38512979
The 1858C>T allele of the tyrosine phosphatase PTPN22 is present in 5-10% of the North American population and is strongly associated with numerous autoimmune diseases. Although research has been done...