Vincent F Vartabedian
Overview
Explore the profile of Vincent F Vartabedian including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
414
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0
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Recent Articles
1.
Shaabani N, Zak J, Johnson J, Huang Z, Nguyen N, Lazar D, et al.
J Immunol
. 2024 Nov;
213(12):1811-1824.
PMID: 39495004
ISG15, an IFN-stimulated gene, plays a crucial role in modulating immune responses during viral infections. Its upregulation is part of the host's defense mechanism against viruses, contributing to the antiviral...
2.
Lazear M, Remsberg J, Jaeger M, Rothamel K, Her H, DeMeester K, et al.
Mol Cell
. 2023 Apr;
83(10):1725-1742.e12.
PMID: 37084731
Most human proteins lack chemical probes, and several large-scale and generalizable small-molecule binding assays have been introduced to address this problem. How compounds discovered in such "binding-first" assays affect protein...
3.
Edgar L, Thompson A, Vartabedian V, Kikuchi C, Woehl J, Teijaro J, et al.
ACS Cent Sci
. 2021 Sep;
7(9):1508-1515.
PMID: 34584952
Effector T cells comprise the cellular arm of the adaptive immune system and are essential for mounting immune responses against pathogens and cancer. To reach effector status, costimulation through CD28...
4.
Shaabani N, Vartabedian V, Nguyen N, Honke N, Huang Z, Teijaro J
Cell Physiol Biochem
. 2021 May;
55(3):256-264.
PMID: 33984198
Background/aims: During an immune response, type I interferon (IFN-I) signaling induces a wide range of changes, including those which are required to overcome viral infection and those which suppress cytotoxic...
5.
Han Z, Thuy-Boun P, Pfeiffer W, Vartabedian V, Torkamani A, Teijaro J, et al.
Sci Rep
. 2021 Feb;
11(1):4763.
PMID: 33637779
N-Acetylneuraminic acid is the most abundant sialic acid (SA) in humans and is expressed as the terminal sugar on intestinal mucus glycans. Several pathogenic bacteria harvest and display host SA...
6.
Chin E, Yu C, Vartabedian V, Jia Y, Kumar M, Gamo A, et al.
Science
. 2020 Aug;
369(6506):993-999.
PMID: 32820126
Stimulator of interferon genes (STING) links innate immunity to biological processes ranging from antitumor immunity to microbiome homeostasis. Mechanistic understanding of the anticancer potential for STING receptor activation is currently...
7.
Pack C, Bommireddy R, Munoz L, Patel J, Bozeman E, Dey P, et al.
Hum Vaccin Immunother
. 2020 Jun;
16(12):3184-3193.
PMID: 32530786
Triple-negative breast cancer (TNBC) afflicts women at a younger age than other breast cancers and is associated with a worse clinical outcome. This poor clinical outcome is attributed to a...
8.
Huang Z, Zak J, Pratumchai I, Shaabani N, Vartabedian V, Nguyen N, et al.
J Exp Med
. 2019 Jun;
216(8):1791-1808.
PMID: 31164392
Chronic infection and cancer are associated with suppressed T cell responses in the presence of cognate antigen. Recent work identified memory-like CXCR5 TCF1 CD8 T cells that sustain T cell...
9.
Ogasawara D, Ichu T, Vartabedian V, Benthuysen J, Jing H, Reed A, et al.
Nat Chem Biol
. 2018 Nov;
14(12):1099-1108.
PMID: 30420694
ABHD12 metabolizes bioactive lysophospholipids, including lysophosphatidylserine (lyso-PS). Deleterious mutations in human ABHD12 cause the neurological disease PHARC, and ABHD12 mice display PHARC-like phenotypes, including hearing loss, along with elevated brain...
10.
Chen J, Genereux J, Suh E, Vartabedian V, Rius B, Qu S, et al.
Cell Chem Biol
. 2016 Oct;
23(10):1282-1293.
PMID: 27720586
Transthyretin (TTR) is a tetrameric serum protein associated with multiple systemic amyloid diseases. In these disorders, TTR aggregates in extracellular environments through a mechanism involving rate-limiting dissociation of the tetramer...