James J-D Hsieh
Overview
Explore the profile of James J-D Hsieh including associated specialties, affiliations and a list of published articles.
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23
Citations
2085
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Recent Articles
1.
Bean G, Ganesan Y, Dong Y, Takeda S, Liu H, Chan P, et al.
Sci Signal
. 2013 Mar;
6(268):ra20.
PMID: 23532334
The clinical efficacy of tyrosine kinase inhibitors supports the dependence of distinct subsets of cancers on specific driver mutations for survival, a phenomenon called "oncogene addiction." We demonstrate that PUMA...
2.
Vanharanta S, Shu W, Brenet F, Hakimi A, Heguy A, Viale A, et al.
Nat Med
. 2012 Dec;
19(1):50-6.
PMID: 23223005
Inactivation of the von Hippel-Lindau tumor suppressor gene, VHL, is an archetypical tumor-initiating event in clear cell renal carcinoma (ccRCC) that leads to the activation of hypoxia-inducible transcription factors (HIFs)....
3.
Chen D, Lee Y, Van Tine B, Searleman A, Westergard T, Liu H, et al.
Cancer Res
. 2011 Dec;
72(3):736-46.
PMID: 22166309
The threonine endopeptidase Taspase1 has a critical role in cancer cell proliferation and apoptosis. In this study, we developed and evaluated small molecule inhibitors of Taspase1 as a new candidate...
4.
Huang G, Zhao X, Wang L, Elf S, Xu H, Zhao X, et al.
Blood
. 2011 Oct;
118(25):6544-52.
PMID: 22012064
The mixed-lineage leukemia (MLL) H3K4 methyltransferase protein, and the heterodimeric RUNX1/CBFβ transcription factor complex, are critical for definitive and adult hematopoiesis, and both are frequently targeted in human acute leukemia....
5.
Ren D, Tu H, Kim H, Wang G, Bean G, Takeuchi O, et al.
Science
. 2010 Dec;
330(6009):1390-3.
PMID: 21127253
Although the proteins BAX and BAK are required for initiation of apoptosis at the mitochondria, how BAX and BAK are activated remains unsettled. We provide in vivo evidence demonstrating an...
6.
Liu H, Takeda S, Kumar R, Westergard T, Brown E, Pandita T, et al.
Nature
. 2010 Sep;
467(7313):343-6.
PMID: 20818375
Cell cycle checkpoints are implemented to safeguard the genome, avoiding the accumulation of genetic errors. Checkpoint loss results in genomic instability and contributes to the evolution of cancer. Among G1-,...
7.
Chen D, Liu H, Takeda S, Tu H, Sasagawa S, Van Tine B, et al.
Cancer Res
. 2010 Jun;
70(13):5358-67.
PMID: 20516119
Taspase1, the mixed lineage leukemia and TFIIAalpha-beta cleaving protease, enables cell proliferation and permits oncogenic initiation. Here, we show its critical role in cancer maintenance and thus offer a new...
8.
Kim H, Tu H, Ren D, Takeuchi O, Jeffers J, Zambetti G, et al.
Mol Cell
. 2009 Nov;
36(3):487-99.
PMID: 19917256
While activation of BAX/BAK by BH3-only molecules (BH3s) is essential for mitochondrial apoptosis, the underlying mechanisms remain unsettled. Here we demonstrate that BAX undergoes stepwise structural reorganization leading to mitochondrial...
9.
Ren D, Kim H, Tu H, Westergard T, Fisher J, Rubens J, et al.
Sci Signal
. 2009 Aug;
2(85):ra48.
PMID: 19706873
The proapoptotic proteins BAX and BAK constitute the mitochondrial apoptotic gateway that executes cellular demise after integrating death signals. The lethal BAK is kept in check by voltage-dependent anion channel...
10.
Lee J, Chen D, Yang Z, Ramos A, Hsieh J, Bogyo M
Bioorg Med Chem Lett
. 2009 Jul;
19(17):5086-90.
PMID: 19631530
Taspase1 is a threonine protease responsible for cleaving MLL (Mixed-Lineage Leukemia) to achieve proper HOX gene expression. Subsequent studies identified additional Taspase1 substrates including Transcription Factor IIA (TFIIA) and Drosophila...