John N Mariani
Overview
Explore the profile of John N Mariani including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
20
Citations
872
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Mariani J, Mansky B, Madsen P, Salinas D, Kesmen D, Huynh N, et al.
Nat Commun
. 2024 May;
15(1):3873.
PMID: 38719882
Human glial progenitor cells (hGPCs) exhibit diminished expansion competence with age, as well as after recurrent demyelination. Using RNA-sequencing to compare the gene expression of fetal and adult hGPCs, we...
2.
Takasugi M, Ohtani N, Takemura K, Emmrich S, Zakusilo F, Yoshida Y, et al.
Cell Rep
. 2023 Sep;
42(9):113130.
PMID: 37708026
The naked mole rat (NMR) is the longest-lived rodent, resistant to multiple age-related diseases including neurodegeneration. However, the mechanisms underlying the NMR's resistance to neurodegenerative diseases remain elusive. Here, we...
3.
Vieira R, Mariani J, Huynh N, Stephensen H, Solly R, Tate A, et al.
Nat Biotechnol
. 2023 Jul;
42(5):719-730.
PMID: 37460676
Competition among adult brain cells has not been extensively researched. To investigate whether healthy glia can outcompete diseased human glia in the adult forebrain, we engrafted wild-type (WT) human glial...
4.
Osorio M, Mariani J, Zou L, Schanz S, Heffernan K, Cornwell A, et al.
Glia
. 2022 Nov;
71(3):524-540.
PMID: 36334067
Genomic analyses have revealed heterogeneity among glial progenitor cells (GPCs), but the compartment selectivity of human GPCs (hGPCs) is unclear. Here, we asked if GPCs of human grey and white...
5.
Benraiss A, Mariani J, Tate A, Madsen P, Clark K, Welle K, et al.
Cell Rep
. 2022 Aug;
40(9):111291.
PMID: 36044851
Huntington's disease (HD) is characterized by defective oligodendroglial differentiation and white matter disease. Here, we investigate the role of oligodendrocyte progenitor cell (OPC) dysfunction in adult myelin maintenance in HD....
6.
Benraiss A, Mariani J, Osipovitch M, Cornwell A, Windrem M, Villanueva C, et al.
Cell Rep
. 2021 Jul;
36(1):109308.
PMID: 34233199
Glial pathology is a causal contributor to the striatal neuronal dysfunction of Huntington's disease (HD). We investigate mutant HTT-associated changes in gene expression by mouse and human striatal astrocytes, as...
7.
Goldman S, Mariani J, Madsen P
Semin Cell Dev Biol
. 2021 Jan;
116:62-70.
PMID: 33414060
Demyelinating disorders of the central white matter are among the most prevalent and disabling conditions in neurology. Since myelin-producing oligodendrocytes comprise the principal cell type deficient or lost in these...
8.
Windrem M, Schanz S, Zou L, Chandler-Militello D, Kuypers N, Nedergaard M, et al.
Cell Rep
. 2020 May;
31(7):107658.
PMID: 32433967
Neonatally transplanted human glial progenitor cells (hGPCs) can myelinate the brains of myelin-deficient shiverer mice, rescuing their phenotype and survival. Yet, it has been unclear whether implanted hGPCs are similarly...
9.
Mariani J, Zou L, Goldman S
Methods Mol Biol
. 2019 Mar;
1936:311-331.
PMID: 30820907
Human glial progenitor cells (hGPCs) can engraft, expand, and differentiate into functional oligodendrocytes and astrocytes when transplanted neonatally into murine hosts, in which they outcompete the host glial pool to...
10.
Osipovitch M, Asenjo Martinez A, Mariani J, Cornwell A, Dhaliwal S, Zou L, et al.
Cell Stem Cell
. 2018 Dec;
24(1):107-122.e7.
PMID: 30554964
Huntington's disease (HD) is characterized by hypomyelination and neuronal loss. To assess the basis for myelin loss in HD, we generated bipotential glial progenitor cells (GPCs) from human embryonic stem...