Abdellatif Benraiss
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Explore the profile of Abdellatif Benraiss including associated specialties, affiliations and a list of published articles.
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28
Citations
1258
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Recent Articles
1.
Huynh N, Osipovitch M, Foti R, Bates J, Mansky B, Cano J, et al.
Brain
. 2024 Jul;
147(9):3099-3112.
PMID: 39028640
Huntington's disease and juvenile-onset schizophrenia have long been regarded as distinct disorders. However, both manifest cell-intrinsic abnormalities in glial differentiation, with resultant astrocytic dysfunction and hypomyelination. To assess whether a...
2.
Mariani J, Mansky B, Madsen P, Salinas D, Kesmen D, Huynh N, et al.
Nat Commun
. 2024 May;
15(1):3873.
PMID: 38719882
Human glial progenitor cells (hGPCs) exhibit diminished expansion competence with age, as well as after recurrent demyelination. Using RNA-sequencing to compare the gene expression of fetal and adult hGPCs, we...
3.
Vieira R, Mariani J, Huynh N, Stephensen H, Solly R, Tate A, et al.
Nat Biotechnol
. 2023 Jul;
42(5):719-730.
PMID: 37460676
Competition among adult brain cells has not been extensively researched. To investigate whether healthy glia can outcompete diseased human glia in the adult forebrain, we engrafted wild-type (WT) human glial...
4.
Villanueva C, Stephensen H, Mokso R, Benraiss A, Sporring J, Goldman S
Proc Natl Acad Sci U S A
. 2023 Jun;
120(24):e2210719120.
PMID: 37279261
Astroglial dysfunction contributes to the pathogenesis of Huntington's disease (HD), and glial replacement can ameliorate the disease course. To establish the topographic relationship of diseased astrocytes to medium spiny neuron...
5.
Benraiss A, Mariani J, Tate A, Madsen P, Clark K, Welle K, et al.
Cell Rep
. 2022 Aug;
40(9):111291.
PMID: 36044851
Huntington's disease (HD) is characterized by defective oligodendroglial differentiation and white matter disease. Here, we investigate the role of oligodendrocyte progenitor cell (OPC) dysfunction in adult myelin maintenance in HD....
6.
Benraiss A, Mariani J, Osipovitch M, Cornwell A, Windrem M, Villanueva C, et al.
Cell Rep
. 2021 Jul;
36(1):109308.
PMID: 34233199
Glial pathology is a causal contributor to the striatal neuronal dysfunction of Huntington's disease (HD). We investigate mutant HTT-associated changes in gene expression by mouse and human striatal astrocytes, as...
7.
Liu Z, Osipovitch M, Benraiss A, Huynh N, Foti R, Bates J, et al.
Cell Rep
. 2019 Jun;
27(13):3832-3843.e6.
PMID: 31242417
Astrocytic differentiation is developmentally impaired in patients with childhood-onset schizophrenia (SCZ). To determine why, we used genetic gain- and loss-of-function studies to establish the contributions of differentially expressed transcriptional regulators...
8.
Banach M, Edholm E, Gonzalez X, Benraiss A, Robert J
Carcinogenesis
. 2019 Jun;
40(7):924-935.
PMID: 31155639
The conditions that lead to antitumor or protumor functions of natural killer T (NKT) cells against mammalian tumors are only partially understood. Therefore, insights into the evolutionary conservation of NKT...
9.
Munk A, Wang W, Bechet N, Eltanahy A, Cheng A, Sigurdsson B, et al.
Cell Rep
. 2019 Mar;
26(11):2955-2969.e3.
PMID: 30865886
The glymphatic system is a highly polarized cerebrospinal fluid (CSF) transport system that facilitates the clearance of neurotoxic molecules through a brain-wide network of perivascular pathways. Herein we have mapped...
10.
Osipovitch M, Asenjo Martinez A, Mariani J, Cornwell A, Dhaliwal S, Zou L, et al.
Cell Stem Cell
. 2018 Dec;
24(1):107-122.e7.
PMID: 30554964
Huntington's disease (HD) is characterized by hypomyelination and neuronal loss. To assess the basis for myelin loss in HD, we generated bipotential glial progenitor cells (GPCs) from human embryonic stem...